Vol 9, No 4 (2005)
Original paper
Published online: 2005-08-05
Chlamydia pneumoniae and cytomegalovirus infection and cardiovascular remodeling in hypertensives
Nadciśnienie tętnicze 2005;9(4):266-275.
Abstract
Background We investigated infuence of Chlamydia
pneumoniae (Ch.p.) and Cytomegalovirus (CMV) infection
on cardiovascular remodeling in essential hypertension.
Material and methods 112 hypertensives were included in the study (age: 55,7 ± 12 y, known duration of hypertension 12,7 ± 8 y). Antibodies against Ch.p, CMV, human HSP60 and ICAM-1, CRP and TNF-α levels were assessed. To assess cardiovascular remodeling following investigations were performed: carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV), left ventricular mass index (LVMI), diastolic function (IVRT — isovolumetric relaxation time, E/A — mitral inflow waves ratio, EDT — E wave deceleration time, AR — reversal flow in pulmonary veins during atrial contraction, S/D pulmonary inflow waves ratio).
Results 66 patients (59%) were seropositive for Ch.p., and 86 (77%) for CMV. Ch.p (+) group had higher IMT values (0,84 vs. 0,93 mm, p = 0,001), lower E/A (0,94 vs. 1/03, p = 0,03) and higher CRP level (1,8 vs. 1,37 mg/l, p = 0,07). After adjusting for age these differences ceased to be significant. CMV (+) group had longer IVRT (96,3 vs. 88,8 ms, p = 0,06), higher PWV (10,5 vs. 9,3 m/s, p = 0,006), lower E/A (0,93 vs. 1,2, p = 0,0001), higher AR (34,9 vs. 30,7 cm/s, p = 0,007), higher CRP (1,8 vs. 1,17 mg, p = 0,037) and ICAM-1 (269,9 vs. 237,2, p = 0,028) levels. After adjusting for age, BMI and cholesterol only differences in E/A, AR and CRP remained significant. There were several significant weak correlations in univariate and multivariate analysis between antibodies levels and indices of remodeling.
Conclusions CMV and Chlamydia pneumoniae infection influences in a small degree both cardiovascular remodeling indices and inflammatory markers in essential hypertensives.
Material and methods 112 hypertensives were included in the study (age: 55,7 ± 12 y, known duration of hypertension 12,7 ± 8 y). Antibodies against Ch.p, CMV, human HSP60 and ICAM-1, CRP and TNF-α levels were assessed. To assess cardiovascular remodeling following investigations were performed: carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV), left ventricular mass index (LVMI), diastolic function (IVRT — isovolumetric relaxation time, E/A — mitral inflow waves ratio, EDT — E wave deceleration time, AR — reversal flow in pulmonary veins during atrial contraction, S/D pulmonary inflow waves ratio).
Results 66 patients (59%) were seropositive for Ch.p., and 86 (77%) for CMV. Ch.p (+) group had higher IMT values (0,84 vs. 0,93 mm, p = 0,001), lower E/A (0,94 vs. 1/03, p = 0,03) and higher CRP level (1,8 vs. 1,37 mg/l, p = 0,07). After adjusting for age these differences ceased to be significant. CMV (+) group had longer IVRT (96,3 vs. 88,8 ms, p = 0,06), higher PWV (10,5 vs. 9,3 m/s, p = 0,006), lower E/A (0,93 vs. 1,2, p = 0,0001), higher AR (34,9 vs. 30,7 cm/s, p = 0,007), higher CRP (1,8 vs. 1,17 mg, p = 0,037) and ICAM-1 (269,9 vs. 237,2, p = 0,028) levels. After adjusting for age, BMI and cholesterol only differences in E/A, AR and CRP remained significant. There were several significant weak correlations in univariate and multivariate analysis between antibodies levels and indices of remodeling.
Conclusions CMV and Chlamydia pneumoniae infection influences in a small degree both cardiovascular remodeling indices and inflammatory markers in essential hypertensives.
Keywords: Chlamydia pneumoniaeCytomegalovirusarterial hypertensionintima-media thicknesspulse wave velocitydiastolic function