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Vol 9, No 4 (2005)
Prace oryginalne
Published online: 2005-08-05
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Effect of 6 weeks treatment with nebivolol on blood pressure reduction and echocardiographic indices in patients with essential hypertension

Elżbieta Florczak, Magdalena Makowiecka-Cieśla, Anna Klisiewicz, Bogna Puciłowska, Rafał Baranowski, Iwona Korzeniowska-Kubacka, Katarzyna Paschalis-Purtak, Hanna Janaszek-Sitkowska, Aleksander Prejbisz, Ewelina Mikocka, Andrzej Januszewicz, Piotr Hoffman
Nadciśnienie tętnicze 2005;9(4):243-251.

open access

Vol 9, No 4 (2005)
Prace oryginalne
Published online: 2005-08-05

Abstract

Background The results of clinical studies comparing antihypertensive efficacy of newer and older beta blockers and their effect on echocardiographic indices are inconclusive. The aim of the study was to evaluate the effect of nebivolol on blood pressure reduction and on selected echocardiographic indices in patients with essential hypertension. The effect of treatment on exercise tolerance was also investigated.
Material and methods The study included 76 male patients with mild to moderate (ESH/ESC: grade 1 and 2) essential hypertension (mean age: 43.6 ± 8.2 years). In all subjects at baseline and after 6 weeks of nebivolol treatment (5 mg once daily) or atenolol (50 mg once daily) (39 and 37 pts respectively) ABPM, Echo, ECG Holter and exercise test were performed.
Results In the nebivolol group SBP and DBP reduction was noticed in 87% and 69% of patients with essential hypertension. Based on ABPM mean SBP and DBP during the whole day, daytime and nighttime decreased: 13 ± 8/8 ± 8 mm Hg, 14 ± 9/10 ± 7 mm Hg and 9 ± 8/6 ± 8 mm Hg respectively (p < 0.01 for all differences).
In the nebivolol group E wave was increased between two examinations from 0.75 ± 0.15 m/s to 0.81 ± 0.2 m/s (p = 0.05), there were no significant changes in A wave 0.66 ± 0.08 m/s vs. 0.64 ± 0.1 m/s (NS).
Ratio E/A was increased during the time of observation from 1.14 ± 0.25 to 1.3 ± 0.23 (p < 0.001).
During the exercise test in the nebivolol group maximal SBP and DBP decreased by 18 ± 26 mm Hg (p < 0.001) and 3 ± 14 mm Hg (NS) respectively after 6 weeks of treatment.
Conclusions Our results indicate high antihypertensive efficacy of nebivolol in patients with essential hypertension. We also observed an improvement of selected echocardiographic indices. Nebivolol was not impairing the exercise tolerance in patients with essential hypertension.

Abstract

Background The results of clinical studies comparing antihypertensive efficacy of newer and older beta blockers and their effect on echocardiographic indices are inconclusive. The aim of the study was to evaluate the effect of nebivolol on blood pressure reduction and on selected echocardiographic indices in patients with essential hypertension. The effect of treatment on exercise tolerance was also investigated.
Material and methods The study included 76 male patients with mild to moderate (ESH/ESC: grade 1 and 2) essential hypertension (mean age: 43.6 ± 8.2 years). In all subjects at baseline and after 6 weeks of nebivolol treatment (5 mg once daily) or atenolol (50 mg once daily) (39 and 37 pts respectively) ABPM, Echo, ECG Holter and exercise test were performed.
Results In the nebivolol group SBP and DBP reduction was noticed in 87% and 69% of patients with essential hypertension. Based on ABPM mean SBP and DBP during the whole day, daytime and nighttime decreased: 13 ± 8/8 ± 8 mm Hg, 14 ± 9/10 ± 7 mm Hg and 9 ± 8/6 ± 8 mm Hg respectively (p < 0.01 for all differences).
In the nebivolol group E wave was increased between two examinations from 0.75 ± 0.15 m/s to 0.81 ± 0.2 m/s (p = 0.05), there were no significant changes in A wave 0.66 ± 0.08 m/s vs. 0.64 ± 0.1 m/s (NS).
Ratio E/A was increased during the time of observation from 1.14 ± 0.25 to 1.3 ± 0.23 (p < 0.001).
During the exercise test in the nebivolol group maximal SBP and DBP decreased by 18 ± 26 mm Hg (p < 0.001) and 3 ± 14 mm Hg (NS) respectively after 6 weeks of treatment.
Conclusions Our results indicate high antihypertensive efficacy of nebivolol in patients with essential hypertension. We also observed an improvement of selected echocardiographic indices. Nebivolol was not impairing the exercise tolerance in patients with essential hypertension.
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Keywords

antihypertensive therapy; nebivolol; echocardiographic indices

About this article
Title

Effect of 6 weeks treatment with nebivolol on blood pressure reduction and echocardiographic indices in patients with essential hypertension

Journal

Arterial Hypertension

Issue

Vol 9, No 4 (2005)

Pages

243-251

Published online

2005-08-05

Bibliographic record

Nadciśnienie tętnicze 2005;9(4):243-251.

Keywords

antihypertensive therapy
nebivolol
echocardiographic indices

Authors

Elżbieta Florczak
Magdalena Makowiecka-Cieśla
Anna Klisiewicz
Bogna Puciłowska
Rafał Baranowski
Iwona Korzeniowska-Kubacka
Katarzyna Paschalis-Purtak
Hanna Janaszek-Sitkowska
Aleksander Prejbisz
Ewelina Mikocka
Andrzej Januszewicz
Piotr Hoffman

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