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The insulin sensitivity and adiponectin in patients with obesity and hypertension
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Abstract
Materials and methods Group 1 — 10 patients with isolated obesity (SBP 127.9 ± 19.6 mm Hg, DBP 79.5 ± 10,9 mm Hg, age 37.6 ± 11.1 years, BMI 36.1 ± 7.3 kg/m2). Group 2 - 17 patients with hypertension and obesity (SBP 171.1 ± 6.8 mm Hg, DBP 92.2 ± 9.4 mm Hg, age 38.6 ± 11.2 years, BMI 33.2 ± 6.9 kg/m2). Control group - 10 healthy person. Insulin sensitivity was measured using the euglicemic metabolic clamp (Ferrannini/de Fronzo). APM1 was measured by RIA (Linco Research, USA).
Results There were no significant differences in M value between group 1 and 2 (3.08 ± 1.11 vs. 2.47 ± 0.32 mg/kg/min), but both results were significantly lower than those in control group (9.4 ± 0.65 mg/kg/min). The APM1 was significantly lower in groups 1 and 2 than in control group (24.8 ± 6.3; 22.2 ± 12.6; 48.5 ± 14.1 mg/ml, respectively). But there were no differences between APM1 in groups 1 and 2. Most significant correlation between APM1 and M was in group 2 (r = 0.62, p < 0.05).
Conclusion Obesity is connected with low insulin sensitivity and hipoadiponectinemia. Comorbidity of obesity and hypertension leads to further lowering of M and APM1 values. The relationship between M and APM1 emphases the role of those adipocytokin in pathogenesis of insulin resistance.
Abstract
Materials and methods Group 1 — 10 patients with isolated obesity (SBP 127.9 ± 19.6 mm Hg, DBP 79.5 ± 10,9 mm Hg, age 37.6 ± 11.1 years, BMI 36.1 ± 7.3 kg/m2). Group 2 - 17 patients with hypertension and obesity (SBP 171.1 ± 6.8 mm Hg, DBP 92.2 ± 9.4 mm Hg, age 38.6 ± 11.2 years, BMI 33.2 ± 6.9 kg/m2). Control group - 10 healthy person. Insulin sensitivity was measured using the euglicemic metabolic clamp (Ferrannini/de Fronzo). APM1 was measured by RIA (Linco Research, USA).
Results There were no significant differences in M value between group 1 and 2 (3.08 ± 1.11 vs. 2.47 ± 0.32 mg/kg/min), but both results were significantly lower than those in control group (9.4 ± 0.65 mg/kg/min). The APM1 was significantly lower in groups 1 and 2 than in control group (24.8 ± 6.3; 22.2 ± 12.6; 48.5 ± 14.1 mg/ml, respectively). But there were no differences between APM1 in groups 1 and 2. Most significant correlation between APM1 and M was in group 2 (r = 0.62, p < 0.05).
Conclusion Obesity is connected with low insulin sensitivity and hipoadiponectinemia. Comorbidity of obesity and hypertension leads to further lowering of M and APM1 values. The relationship between M and APM1 emphases the role of those adipocytokin in pathogenesis of insulin resistance.
Keywords
adiponectin; insulin sensitivity; obesity; hypertension
About this articleTitle
The insulin sensitivity and adiponectin in patients with obesity and hypertension
Journal
Issue
Article type
Original paper
Pages
350-355
Published online
2005-09-29
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656
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Bibliographic record
Nadciśnienie tętnicze 2005;9(5):350-355.
Keywords
adiponectin
insulin sensitivity
obesity
hypertension
Authors
Anna Miczke
Wiesław Bryl
Monika Szulińska
Maciej Cymerys
Karolina Hoffmann
Danuta Pupek-Musialik
Olga Trojnarska