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The relationship between kidney volume and insulinemia in nontreated essential hypertensives
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Abstract
Materials and methods The aim of the study was to evaluate the relationship between concentration of insulin in blood serum or kidneys volume in patiens with non-treated primary hypertension and healthy persons. The study covered 25 patients with non-treated primary hypertension. A control group consisted of 14 health volunteers. In both groups, kidneys volume was measured by USG, moreover, blood samples were taken from a vein in fasting state in order to evaluate the concentration of insulin, glucose and creatinine. In both groups, urine was collected over 24 hrs and the excretion of N-acetyl-beta-D-glucaminidase (NAG) and creatinine was assessed. Results Insulin/Glucose Index as well as the excretion of NAG were significantly higher in patiens with non-treated primary overpressure as compared to the control group. Also, there were significant differences in the ratio of Kidney Volume to Body Mass Index in patients with nontreated overpressure and the control group, the above differences resulted from much higher BMI in the group of patients with overpressure. Only in patients with overpressure correlation between insulinemia and KV/BMI amounted (r = 0.441; p < 0.05).
Conclusions Primary hypertension leads to disfunction of kidney ducts. Such disfunction may contribute to disturbances in carbohydrates transformation observed in cases of arterial hypertension.
Abstract
Materials and methods The aim of the study was to evaluate the relationship between concentration of insulin in blood serum or kidneys volume in patiens with non-treated primary hypertension and healthy persons. The study covered 25 patients with non-treated primary hypertension. A control group consisted of 14 health volunteers. In both groups, kidneys volume was measured by USG, moreover, blood samples were taken from a vein in fasting state in order to evaluate the concentration of insulin, glucose and creatinine. In both groups, urine was collected over 24 hrs and the excretion of N-acetyl-beta-D-glucaminidase (NAG) and creatinine was assessed. Results Insulin/Glucose Index as well as the excretion of NAG were significantly higher in patiens with non-treated primary overpressure as compared to the control group. Also, there were significant differences in the ratio of Kidney Volume to Body Mass Index in patients with nontreated overpressure and the control group, the above differences resulted from much higher BMI in the group of patients with overpressure. Only in patients with overpressure correlation between insulinemia and KV/BMI amounted (r = 0.441; p < 0.05).
Conclusions Primary hypertension leads to disfunction of kidney ducts. Such disfunction may contribute to disturbances in carbohydrates transformation observed in cases of arterial hypertension.
Keywords
essentials hypertensive; diabetes mellitus; kidney volume; insulin
Title
The relationship between kidney volume and insulinemia in nontreated essential hypertensives
Journal
Issue
Article type
Original paper
Pages
335-339
Published online
2005-09-29
Page views
678
Article views/downloads
1672
Bibliographic record
Nadciśnienie tętnicze 2005;9(5):335-339.
Keywords
essentials hypertensive
diabetes mellitus
kidney volume
insulin
Authors
Michał Kozłowski
Marek Kretowicz
Paweł Stróżecki
Małgorzata Ukleja-Adamowicz
Krzysztof Buczkowski
Grażyna Odrowąż-Sypniewska
Jacek Manitius