Assessment of the influence of selected developmental parameters in newborns on impoper daily blood pressure variability in hypertensive children

Łukasz Krzych; Małgorzata Kowalska; Lesław Szydłowski; Grażyna Markiewicz-Łoskot

Vol 10, No 1 (2006)

Original paper

Published online: 2006-01-28

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Assessment of the influence of selected developmental parameters in newborns on impoper daily blood pressure variability in hypertensive children

Łukasz Krzych, Małgorzata Kowalska, Lesław Szydłowski, Grażyna Markiewicz-Łoskot

Nadciśnienie tętnicze 2006;10(1):30-34.

Vol 10, No 1 (2006)

Prace oryginalne

Published online: 2006-01-28

Abstract

Background Hypertension is an important problem both in children and adults. Improper blood pressure (BP) variability deteriorates the clinical outcome and progress of hypertension. In the light of theory of "fetal origins of hypertension", the estimation of developmental neonatal parameters may identify the group of children with increased cardio-vascular risk related to improper BP variability in the early stage of hypertension. The aim of the study was to assess the infuence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children.
Material and methods The project was conducted retrospectively as a case-control study in 106 children (aged 15.4 ± 2.0) with primary hypertension. The study group included 58 children with improper BP variability ("non-dippers") and 48 "dippers" as the control group. The statistical analysis was performed with EpiInfo 6,0 procedures.
Results No influence of low birth weight, low birth lenght, low Apgar score and prematurity on improper daily blood pressure variability in hypertensive children was observed. However, "non-dippers" had statistically significantly higher average birth weight and birth lenght than "dippers", adequately: 3343.5 ± 532.5 g vs. 3024.4 ± 611.4 g and 55.4 ± 3.0 cm vs. 52.1 ± 3.5 cm. Family history of hypertension did not increase the risk of "non-dipping": OR = 0.88 (95% CI: 0.35-2.23, p > 0.05). Conclusions The results suggest that the role of low birth weight, low birth lenght, low Apgar score and prematurity in the development of improper daily blood pressure variability in hypertensive children is doubtful. More adequate assessment of the influence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children needs further clinical investigations.