open access

Vol 10, No 1 (2006)
Prace oryginalne
Published online: 2006-01-28
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Assessment of the influence of selected developmental parameters in newborns on impoper daily blood pressure variability in hypertensive children

Łukasz Krzych, Małgorzata Kowalska, Lesław Szydłowski, Grażyna Markiewicz-Łoskot
Nadciśnienie tętnicze 2006;10(1):30-34.

open access

Vol 10, No 1 (2006)
Prace oryginalne
Published online: 2006-01-28

Abstract

Background Hypertension is an important problem both in children and adults. Improper blood pressure (BP) variability deteriorates the clinical outcome and progress of hypertension. In the light of theory of "fetal origins of hypertension", the estimation of developmental neonatal parameters may identify the group of children with increased cardio-vascular risk related to improper BP variability in the early stage of hypertension. The aim of the study was to assess the infuence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children.
Material and methods The project was conducted retrospectively as a case-control study in 106 children (aged 15.4 ± 2.0) with primary hypertension. The study group included 58 children with improper BP variability ("non-dippers") and 48 "dippers" as the control group. The statistical analysis was performed with EpiInfo 6,0 procedures.
Results No influence of low birth weight, low birth lenght, low Apgar score and prematurity on improper daily blood pressure variability in hypertensive children was observed. However, "non-dippers" had statistically significantly higher average birth weight and birth lenght than "dippers", adequately: 3343.5 ± 532.5 g vs. 3024.4 ± 611.4 g and 55.4 ± 3.0 cm vs. 52.1 ± 3.5 cm. Family history of hypertension did not increase the risk of "non-dipping": OR = 0.88 (95% CI: 0.35-2.23, p > 0.05). Conclusions The results suggest that the role of low birth weight, low birth lenght, low Apgar score and prematurity in the development of improper daily blood pressure variability in hypertensive children is doubtful. More adequate assessment of the influence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children needs further clinical investigations.

Abstract

Background Hypertension is an important problem both in children and adults. Improper blood pressure (BP) variability deteriorates the clinical outcome and progress of hypertension. In the light of theory of "fetal origins of hypertension", the estimation of developmental neonatal parameters may identify the group of children with increased cardio-vascular risk related to improper BP variability in the early stage of hypertension. The aim of the study was to assess the infuence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children.
Material and methods The project was conducted retrospectively as a case-control study in 106 children (aged 15.4 ± 2.0) with primary hypertension. The study group included 58 children with improper BP variability ("non-dippers") and 48 "dippers" as the control group. The statistical analysis was performed with EpiInfo 6,0 procedures.
Results No influence of low birth weight, low birth lenght, low Apgar score and prematurity on improper daily blood pressure variability in hypertensive children was observed. However, "non-dippers" had statistically significantly higher average birth weight and birth lenght than "dippers", adequately: 3343.5 ± 532.5 g vs. 3024.4 ± 611.4 g and 55.4 ± 3.0 cm vs. 52.1 ± 3.5 cm. Family history of hypertension did not increase the risk of "non-dipping": OR = 0.88 (95% CI: 0.35-2.23, p > 0.05). Conclusions The results suggest that the role of low birth weight, low birth lenght, low Apgar score and prematurity in the development of improper daily blood pressure variability in hypertensive children is doubtful. More adequate assessment of the influence of selected neonatal biological parameters on improper daily blood pressure variability in hypertensive children needs further clinical investigations.
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Keywords

hypertension; blood pressure variability; low birth weight; Apgar score; prematurity

About this article
Title

Assessment of the influence of selected developmental parameters in newborns on impoper daily blood pressure variability in hypertensive children

Journal

Arterial Hypertension

Issue

Vol 10, No 1 (2006)

Pages

30-34

Published online

2006-01-28

Bibliographic record

Nadciśnienie tętnicze 2006;10(1):30-34.

Keywords

hypertension
blood pressure variability
low birth weight
Apgar score
prematurity

Authors

Łukasz Krzych
Małgorzata Kowalska
Lesław Szydłowski
Grażyna Markiewicz-Łoskot

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