open access

Vol 10, No 2 (2006)
Prace oryginalne
Published online: 2006-04-18
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Influence of selected genetic polymorphisms of angiotensinogen, angiotensin-converting enzyme and type-1 angiotensin II receptor on arterial pressure and large artery stiffness parameters - depending on sodium intake

Marcin Cwynar, Wiktoria Wojciechowska, Katarzyna Stolarz, Barbara Wizner, Kalina Kawecka-Jaszcz, Jan A. Staessen, Tomasz Grodzicki
Nadciśnienie tętnicze 2006;10(2):99-110.

open access

Vol 10, No 2 (2006)
Prace oryginalne
Published online: 2006-04-18

Abstract

Background In a population-based and family-based approach we investigated, to what extent blood pressure and large artery stiffness relate to the AGT G-6A, ACE D/I and AGT1R A1166C gene polymorphisms, as well as the interaction between genetic and environmental factors and their joint influence on the aforementioned parameters.
Materials and methods We recruited 52 families (82 parents and 103 offspring). Peripheral pressures were derived from conventional and 24h-ambulatory blood pressure measurements, respectively. Central pressures and large artery stiffness parameters were assessed by pulse wave analysis. All participants collected a 24-h urine sample for the measurement of sodium excretion as well as blood sample for the evaluation of genetic analyses.
Results In single gene analyzes, significant findings were revealed for ACE D/I polymorphism with respect to 24h-ambulatory and central systolic (SBPA, SBPC) and pulse (PPA, PPC) pressures. In further analyzes, we found an interaction between ACE D/I genotype and 24-h urinary sodium excretion in relation to SBPC, conventional pulse pressure (PPP), PPC and augmentation pressure (AG). In the third tertile of the distribution of sodium excretion we observed significantly increased SBPC, PPP, PPA, PPC and AG in ACE II homozygotes compared to D allele carriers, which was not observed in first and second tertile.
Conclusions In the examined group, the interactions between D/I polymorphism of the ACE gene and daily sodium excretion in the urine were revealed, in relation to the parameters of blood pressure and arterial wall stiffness.The D allele of ACE gene showed a protective role in the group of subjects with high daily sodium intake.

Abstract

Background In a population-based and family-based approach we investigated, to what extent blood pressure and large artery stiffness relate to the AGT G-6A, ACE D/I and AGT1R A1166C gene polymorphisms, as well as the interaction between genetic and environmental factors and their joint influence on the aforementioned parameters.
Materials and methods We recruited 52 families (82 parents and 103 offspring). Peripheral pressures were derived from conventional and 24h-ambulatory blood pressure measurements, respectively. Central pressures and large artery stiffness parameters were assessed by pulse wave analysis. All participants collected a 24-h urine sample for the measurement of sodium excretion as well as blood sample for the evaluation of genetic analyses.
Results In single gene analyzes, significant findings were revealed for ACE D/I polymorphism with respect to 24h-ambulatory and central systolic (SBPA, SBPC) and pulse (PPA, PPC) pressures. In further analyzes, we found an interaction between ACE D/I genotype and 24-h urinary sodium excretion in relation to SBPC, conventional pulse pressure (PPP), PPC and augmentation pressure (AG). In the third tertile of the distribution of sodium excretion we observed significantly increased SBPC, PPP, PPA, PPC and AG in ACE II homozygotes compared to D allele carriers, which was not observed in first and second tertile.
Conclusions In the examined group, the interactions between D/I polymorphism of the ACE gene and daily sodium excretion in the urine were revealed, in relation to the parameters of blood pressure and arterial wall stiffness.The D allele of ACE gene showed a protective role in the group of subjects with high daily sodium intake.
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Keywords

ACE; D/I polymorphism; arterial pressure; arterial stiffness; sodium intake

About this article
Title

Influence of selected genetic polymorphisms of angiotensinogen, angiotensin-converting enzyme and type-1 angiotensin II receptor on arterial pressure and large artery stiffness parameters - depending on sodium intake

Journal

Arterial Hypertension

Issue

Vol 10, No 2 (2006)

Pages

99-110

Published online

2006-04-18

Bibliographic record

Nadciśnienie tętnicze 2006;10(2):99-110.

Keywords

ACE
D/I polymorphism
arterial pressure
arterial stiffness
sodium intake

Authors

Marcin Cwynar
Wiktoria Wojciechowska
Katarzyna Stolarz
Barbara Wizner
Kalina Kawecka-Jaszcz
Jan A. Staessen
Tomasz Grodzicki

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