Vol 10, No 4 (2006)
Review paper
Published online: 2006-08-08
Resistin - the role in development of insulin resistance - facts and controversy
Monika Szulińska, Danuta Pupek-Musialik
Nadciśnienie tętnicze 2006;10(4):301-306.
Vol 10, No 4 (2006)
REVIEV
Published online: 2006-08-08
Abstract
In a view of recent studies adipose tissue should be treated
as endocrine organ producing many active substances. It is
postulated that one of them - resistin can play potential
role in the mechanism leading to insulin resistance.
The resistin gene, located on 19 chromosome locus 13.2,
consist of 4 exons.
Some studies using mice model of obesity, hypertension
and type 2 diabetes have suggested that resistin could be an
important link between increased fat mass and insulin resistance.
However, there are not many available data from
studies of blood resistin concentrations in human, and it is
not clear whether the physiology of resistin in mice is relevant
to that in human.
The resistin plasma concentration is increased in obesity,
type 2 diabetes, insulin resistance.
Resistin, which has recently been proposed to play a role in
obesity-mediated insulin resistance, has a structure similar
to that of proteins that are involved in inflammatory processes.
The role of resistin in physiology and patology connected
with metabolic disorders and its consequences requires further
studies.
Abstract
In a view of recent studies adipose tissue should be treated
as endocrine organ producing many active substances. It is
postulated that one of them - resistin can play potential
role in the mechanism leading to insulin resistance.
The resistin gene, located on 19 chromosome locus 13.2,
consist of 4 exons.
Some studies using mice model of obesity, hypertension
and type 2 diabetes have suggested that resistin could be an
important link between increased fat mass and insulin resistance.
However, there are not many available data from
studies of blood resistin concentrations in human, and it is
not clear whether the physiology of resistin in mice is relevant
to that in human.
The resistin plasma concentration is increased in obesity,
type 2 diabetes, insulin resistance.
Resistin, which has recently been proposed to play a role in
obesity-mediated insulin resistance, has a structure similar
to that of proteins that are involved in inflammatory processes.
The role of resistin in physiology and patology connected
with metabolic disorders and its consequences requires further
studies.
Keywords
resistin; obesity; insulin resistance; inflammatory
Title
Resistin - the role in development of insulin resistance - facts and controversy
Journal
Arterial Hypertension
Issue
Vol 10, No 4 (2006)
Article type
Review paper
Pages
301-306
Published online
2006-08-08
Page views
1020
Article views/downloads
7683
Bibliographic record
Nadciśnienie tętnicze 2006;10(4):301-306.
Keywords
resistin
obesity
insulin resistance
inflammatory
Authors
Monika Szulińska
Danuta Pupek-Musialik