open access

Vol 10, No 6 (2006)
REVIEV
Published online: 2007-01-11
Get Citation

Advantages concerning therapy with angiotensin II receptor 1 blockers in patients with arterial hypertension and chronic nephropathy

Andrzej Więcek, Jerzy Chudek
Nadciśnienie tętnicze 2006;10(6):541-550.

open access

Vol 10, No 6 (2006)
REVIEV
Published online: 2007-01-11

Abstract

Angiotensin II receptor 1 blockers named sartans, among other antihypertensive drugs, poses a special nephroprotective properties. Both sartans and inhibitors of angiotensin converting enzyme improves glomerular hemodynamics and present a variety of beneficial nonhemodynamic effects that decreasing proteinuria and slowing glomerular fibrosis. In several prospective, randomized trials, it was shown that sartans slow the progression of diabetic nephropathy. It can be also presumed that sartans exert similar effects in patients with nondiabetic chronic nephropathy. However clinical trials with limited number of patients with chronic nephropathy were disable to prove, whether obtained nephroprotection effect is followed by the improvement of patients survival.

Abstract

Angiotensin II receptor 1 blockers named sartans, among other antihypertensive drugs, poses a special nephroprotective properties. Both sartans and inhibitors of angiotensin converting enzyme improves glomerular hemodynamics and present a variety of beneficial nonhemodynamic effects that decreasing proteinuria and slowing glomerular fibrosis. In several prospective, randomized trials, it was shown that sartans slow the progression of diabetic nephropathy. It can be also presumed that sartans exert similar effects in patients with nondiabetic chronic nephropathy. However clinical trials with limited number of patients with chronic nephropathy were disable to prove, whether obtained nephroprotection effect is followed by the improvement of patients survival.
Get Citation

Keywords

diabetic nephropathy; chronic nephropathy; proteinuria; GFR decline; angiotensin II receptor blocker

About this article
Title

Advantages concerning therapy with angiotensin II receptor 1 blockers in patients with arterial hypertension and chronic nephropathy

Journal

Arterial Hypertension

Issue

Vol 10, No 6 (2006)

Pages

541-550

Published online

2007-01-11

Bibliographic record

Nadciśnienie tętnicze 2006;10(6):541-550.

Keywords

diabetic nephropathy
chronic nephropathy
proteinuria
GFR decline
angiotensin II receptor blocker

Authors

Andrzej Więcek
Jerzy Chudek

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl