open access

Vol 11, No 1 (2007)
Prace oryginalne
Published online: 2007-01-24
Get Citation

Modification of arterial smooth muscle reactivity in cyclosporine A pretreated arteries

Grzegorz Grześk, Iwona Świątkiewicz, Maciej Słupski, Sławomir Manysiak, Michał Wiciński, Katarzyna Szadujkis-Szadurska, Grażyna Odrowąż-Sypniewska, Leszek Szadujkis-Szadurski
Nadciśnienie tętnicze 2007;11(1):21-26.

open access

Vol 11, No 1 (2007)
Prace oryginalne
Published online: 2007-01-24

Abstract


Background In the present study the interactions between phenylephrine - selective α1-adrenoceptor agonist, arg-vasopressine - selective agonist of vasopressine receptor type 1 (V1) and modulator - cyclosporine A were investigated.
Material and methods Experiments were performed on perfused rat tail arteries. Using classical pharmacometric methods the relationship between concentration-response curves (CRCs) for agonists performed in the absence and presence of cyclosporine A were analyzed.
Results In the presence of cyclosporine A the reduction in ED50 values for agonists was observed. Dissociation constants for agonists calculated in the presence of cyclosporine A did not differ significantly from controls.
Conclusions Changes in plots of agonists responses against receptor occupancy for agonists and changes in KA/ED50 value suggest increase in receptor reserve. This increase was not significantly reduced in the presence of losartan. Our results suggest that changes in receptor reserve are result of changes in signal transduction.

Abstract


Background In the present study the interactions between phenylephrine - selective α1-adrenoceptor agonist, arg-vasopressine - selective agonist of vasopressine receptor type 1 (V1) and modulator - cyclosporine A were investigated.
Material and methods Experiments were performed on perfused rat tail arteries. Using classical pharmacometric methods the relationship between concentration-response curves (CRCs) for agonists performed in the absence and presence of cyclosporine A were analyzed.
Results In the presence of cyclosporine A the reduction in ED50 values for agonists was observed. Dissociation constants for agonists calculated in the presence of cyclosporine A did not differ significantly from controls.
Conclusions Changes in plots of agonists responses against receptor occupancy for agonists and changes in KA/ED50 value suggest increase in receptor reserve. This increase was not significantly reduced in the presence of losartan. Our results suggest that changes in receptor reserve are result of changes in signal transduction.
Get Citation

Keywords

cyclosporine-A; α1-adrenoceptors; vasopressine receptors; receptor reserve

About this article
Title

Modification of arterial smooth muscle reactivity in cyclosporine A pretreated arteries

Journal

Arterial Hypertension

Issue

Vol 11, No 1 (2007)

Pages

21-26

Published online

2007-01-24

Bibliographic record

Nadciśnienie tętnicze 2007;11(1):21-26.

Keywords

cyclosporine-A
α1-adrenoceptors
vasopressine receptors
receptor reserve

Authors

Grzegorz Grześk
Iwona Świątkiewicz
Maciej Słupski
Sławomir Manysiak
Michał Wiciński
Katarzyna Szadujkis-Szadurska
Grażyna Odrowąż-Sypniewska
Leszek Szadujkis-Szadurski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl