open access

Vol 11, No 1 (2007)
Artykuły redakcyjne
Published online: 2007-01-24
Get Citation

The role of the blood viscosity in the pathogenesis of the arterial hypertension

Marek Rajzer, Ilona Palka, Kalina Kawecka-Jaszcz
Nadciśnienie tętnicze 2007;11(1):1-11.

open access

Vol 11, No 1 (2007)
Artykuły redakcyjne
Published online: 2007-01-24

Abstract

Blood viscosity, the principal physical property of each fluid, is the force acting against the flow which defines the flow conditions in whole circulatory system. Blood viscosity is influenced by external factors like temperature, flow velocity and oscillations but mainly depends on blood itself i. e. the value of hematocrite, red blood cell deformability and plasma proteins composition. Hematology was the first branch of medicine interested in blood viscosity thus blood viscosity disturbances are most widely described in hematological disorders. Composite haemorheologic disturbances are observed in numerous cardiovascular diseases too. Importance of the blood viscosity is emphasized in the pathogenesis of atherosclerosis, and its cardio-vascular complications including acute myocardial infarction and ischaemic stroke as well as in diabetes, metabolic syndrome and hyperlipidemia. Blood viscosity disturbances are commonly considered as clinical steady components of the arterial hypertension especially in the more advanced stages (ESH/ESC 2 and 3 stage). Factors responsible for elevated blood viscosity in patients with arterial hypertension include elevated hematocrite values and hyperfibrynogenemia. According to Poiseuille’s law, blood viscosity increases systemic blood pressure via increased vascular resistance. On the other hand blood viscosity is necessary for shear stress forces development between blood and vascular wall. Shear stress acts on vascular endothelium where increases the synthesis of vasodilators (mechanotransduction). The role of blood viscosity in blood pressure regulation is composite. Pathological increase in blood viscosity is responsible for hypertensive complications and remains in strong correlation with total mortality among hypertensive patients. The influence on blood viscosity can be important in antihypertensive therapy. The influence of new antihypertensive drugs on blood viscosity is considered to be positive. However, results from the research carried out up to now need to be confirmed in prospective randomized clinical trials.

Abstract

Blood viscosity, the principal physical property of each fluid, is the force acting against the flow which defines the flow conditions in whole circulatory system. Blood viscosity is influenced by external factors like temperature, flow velocity and oscillations but mainly depends on blood itself i. e. the value of hematocrite, red blood cell deformability and plasma proteins composition. Hematology was the first branch of medicine interested in blood viscosity thus blood viscosity disturbances are most widely described in hematological disorders. Composite haemorheologic disturbances are observed in numerous cardiovascular diseases too. Importance of the blood viscosity is emphasized in the pathogenesis of atherosclerosis, and its cardio-vascular complications including acute myocardial infarction and ischaemic stroke as well as in diabetes, metabolic syndrome and hyperlipidemia. Blood viscosity disturbances are commonly considered as clinical steady components of the arterial hypertension especially in the more advanced stages (ESH/ESC 2 and 3 stage). Factors responsible for elevated blood viscosity in patients with arterial hypertension include elevated hematocrite values and hyperfibrynogenemia. According to Poiseuille’s law, blood viscosity increases systemic blood pressure via increased vascular resistance. On the other hand blood viscosity is necessary for shear stress forces development between blood and vascular wall. Shear stress acts on vascular endothelium where increases the synthesis of vasodilators (mechanotransduction). The role of blood viscosity in blood pressure regulation is composite. Pathological increase in blood viscosity is responsible for hypertensive complications and remains in strong correlation with total mortality among hypertensive patients. The influence on blood viscosity can be important in antihypertensive therapy. The influence of new antihypertensive drugs on blood viscosity is considered to be positive. However, results from the research carried out up to now need to be confirmed in prospective randomized clinical trials.
Get Citation

Keywords

whole blood viscosity; plasma viscosity; arterial hypertension; antihypertensive drugs

About this article
Title

The role of the blood viscosity in the pathogenesis of the arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 11, No 1 (2007)

Pages

1-11

Published online

2007-01-24

Bibliographic record

Nadciśnienie tętnicze 2007;11(1):1-11.

Keywords

whole blood viscosity
plasma viscosity
arterial hypertension
antihypertensive drugs

Authors

Marek Rajzer
Ilona Palka
Kalina Kawecka-Jaszcz

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl