The possibilities of proteinuria reduction in hypertensive patients in light of large clinical trials

Abstract

Proteinuria may be of glomerular or tubular origin but may be also caused by endothelial damage. Hypertension is a known cause of proteinuria, especially microalbuminuria. This is associated with a greater cardiovascular mortality. This review is dedicated to the possibilities of reducing proteinuria in hypertensive patients. It concisely states the results of large up to date clinical trials. A proteinuric hypertensive patient should have the best possible blood pressure control. The drugs of choice are ACE-inhibitors and AT1-blockers, especially in combination.