open access

Vol 11, No 3 (2007)
REVIEV
Published online: 2007-05-31
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Influence of hypotensive drugs on bone mineral density and fracture risk in patients with arterial hypertension

Karolina Jankowska, Artur Radziemski, Jerzy Głuszek
Nadciśnienie tętnicze 2007;11(3):248-253.

open access

Vol 11, No 3 (2007)
REVIEV
Published online: 2007-05-31

Abstract

Hypertension is connected with calcium metabolism disorders. The most frequent abnormity is increased renal calcium loss. Hypercalciuria may lead to decreased mineral bone density and its consequence-increased fracture risk. Hypotensive treatment can protect from this occurrences. It is not clear which group of hypotensive drugs demonstrates the best protection. The interaction with calcium channel blockers may be expected. Positive effects of thiazide diuretics are known. Calcium metabolism is also dependent on sympathetic nervous system and renin-angiotensin-aldosteron system. So potentially every group of drugs used for hypertension treatment can play a role in calcium metabolism. This paper presents the results of previous and current studies concerning an influence of hypotensive drugs on bone mineral density and fracture risk.

Abstract

Hypertension is connected with calcium metabolism disorders. The most frequent abnormity is increased renal calcium loss. Hypercalciuria may lead to decreased mineral bone density and its consequence-increased fracture risk. Hypotensive treatment can protect from this occurrences. It is not clear which group of hypotensive drugs demonstrates the best protection. The interaction with calcium channel blockers may be expected. Positive effects of thiazide diuretics are known. Calcium metabolism is also dependent on sympathetic nervous system and renin-angiotensin-aldosteron system. So potentially every group of drugs used for hypertension treatment can play a role in calcium metabolism. This paper presents the results of previous and current studies concerning an influence of hypotensive drugs on bone mineral density and fracture risk.
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Keywords

hypertension; mineral bone density; fractures; hypotensive drugs

About this article
Title

Influence of hypotensive drugs on bone mineral density and fracture risk in patients with arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 11, No 3 (2007)

Pages

248-253

Published online

2007-05-31

Bibliographic record

Nadciśnienie tętnicze 2007;11(3):248-253.

Keywords

hypertension
mineral bone density
fractures
hypotensive drugs

Authors

Karolina Jankowska
Artur Radziemski
Jerzy Głuszek

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