Influence of hypotensive drugs on bone mineral density and fracture risk in patients with arterial hypertension

Abstract

Hypertension is connected with calcium metabolism disorders. The most frequent abnormity is increased renal calcium loss. Hypercalciuria may lead to decreased mineral bone density and its consequence-increased fracture risk. Hypotensive treatment can protect from this occurrences. It is not clear which group of hypotensive drugs demonstrates the best protection. The interaction with calcium channel blockers may be expected. Positive effects of thiazide diuretics are known. Calcium metabolism is also dependent on sympathetic nervous system and renin-angiotensin-aldosteron system. So potentially every group of drugs used for hypertension treatment can play a role in calcium metabolism. This paper presents the results of previous and current studies concerning an influence of hypotensive drugs on bone mineral density and fracture risk.