open access

Vol 11, No 3 (2007)
REVIEV
Published online: 2007-05-31
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The renin-angiotensin-aldosterone system (RAAS) - new pathogenetic and therapeutic aspects Part. I. Prorenin and renin and its receptors, convertase 2 of angiotensin-1-10, angiotensin-1-7 and its receptor, visceral fat tissue as a site of synthesis of RAAS components

Lidia Hyla-Klekot, Barbara Pulcer, Franciszek Kokot
Nadciśnienie tętnicze 2007;11(3):242-247.

open access

Vol 11, No 3 (2007)
REVIEV
Published online: 2007-05-31

Abstract

The role of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of arterial hypertension, cardiovascular abnormalities, water-electrolyte disturbances, and many other pathological settings has been known for many years. In the last ten years new functions of the RAAS were discovered which may be of essential therapeutic relevance. Among them the following are worth mentioning: discovery and function of prorenin-renin receptors, angiotensin-1-7 and its receptor, converting enzyme 2 of angiotensin-1-10, identification of visceral fat tissue as a site of RAAS components synthesis and discovery of many pathogenetic effects of aldosterone, not related to the hypertensogenic action of this hormone. In this overview potential pathogenetic and therapeutic implication of the above mentioned new facts concerning RAAS are discussed.

Abstract

The role of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of arterial hypertension, cardiovascular abnormalities, water-electrolyte disturbances, and many other pathological settings has been known for many years. In the last ten years new functions of the RAAS were discovered which may be of essential therapeutic relevance. Among them the following are worth mentioning: discovery and function of prorenin-renin receptors, angiotensin-1-7 and its receptor, converting enzyme 2 of angiotensin-1-10, identification of visceral fat tissue as a site of RAAS components synthesis and discovery of many pathogenetic effects of aldosterone, not related to the hypertensogenic action of this hormone. In this overview potential pathogenetic and therapeutic implication of the above mentioned new facts concerning RAAS are discussed.
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Keywords

renin-angiotensin-aldosterone system (RAAS); prorenin; renin angiotensin converting enzyme 2; angiotensin-1-7; angiotensin II; visceral fat tissue as a potential site of RAAS components synthesis.

About this article
Title

The renin-angiotensin-aldosterone system (RAAS) - new pathogenetic and therapeutic aspects Part. I. Prorenin and renin and its receptors, convertase 2 of angiotensin-1-10, angiotensin-1-7 and its receptor, visceral fat tissue as a site of synthesis of RAAS components

Journal

Arterial Hypertension

Issue

Vol 11, No 3 (2007)

Pages

242-247

Published online

2007-05-31

Bibliographic record

Nadciśnienie tętnicze 2007;11(3):242-247.

Keywords

renin-angiotensin-aldosterone system (RAAS)
prorenin
renin angiotensin converting enzyme 2
angiotensin-1-7
angiotensin II
visceral fat tissue as a potential site of RAAS components synthesis.

Authors

Lidia Hyla-Klekot
Barbara Pulcer
Franciszek Kokot

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