open access
Role of aldosterone and bradykinin in pathogenesis of left ventricular hypertrophy in patients with primary hypertension
open access
Abstract
Background Left ventricular hypertrophy (LVH) as a result of hypertension (HT) is a relevant risk factor for cardiovascular complications. The aim of the study was to assess the role of aldosterone and bradykinin in the pathogenesis of LVH in patients in different stages of HT.
Material and methods The investigations were carried out in 100 hypertensive patients (56 male, 44 female) including 34 patients with mild, 45 with moderate, 21 with severe HT. 31 healthy individuals served as controls. Each subject underwent echocardiographic examination and evaluation of aldosterone serum (ALDO) and bradykinin plasma concentration (BRADY) by radioimmunoassay.
Results Left ventricular hypertrophy was found in 48 patients. ALDO and BRADY were significantly higher in hypertensives with LVH than in the group without LVH. In multivariate analysis ALDO as well as BRADY correlated positively and independently with LVM and LVMI only in the group of severe HT. Independent correlations between BRADY and left ventricular ejection fraction (EF) in the whole group of HT as well as in the control group HT were observed.
Conclusions The results of the study indicate the role of aldosterone in the process of LVH. The role of bradykinin as a part of neurohumoral counterregulation in cardiac remodelling is also possible.
Abstract
Background Left ventricular hypertrophy (LVH) as a result of hypertension (HT) is a relevant risk factor for cardiovascular complications. The aim of the study was to assess the role of aldosterone and bradykinin in the pathogenesis of LVH in patients in different stages of HT.
Material and methods The investigations were carried out in 100 hypertensive patients (56 male, 44 female) including 34 patients with mild, 45 with moderate, 21 with severe HT. 31 healthy individuals served as controls. Each subject underwent echocardiographic examination and evaluation of aldosterone serum (ALDO) and bradykinin plasma concentration (BRADY) by radioimmunoassay.
Results Left ventricular hypertrophy was found in 48 patients. ALDO and BRADY were significantly higher in hypertensives with LVH than in the group without LVH. In multivariate analysis ALDO as well as BRADY correlated positively and independently with LVM and LVMI only in the group of severe HT. Independent correlations between BRADY and left ventricular ejection fraction (EF) in the whole group of HT as well as in the control group HT were observed.
Conclusions The results of the study indicate the role of aldosterone in the process of LVH. The role of bradykinin as a part of neurohumoral counterregulation in cardiac remodelling is also possible.
Keywords
aldosterone; bradykinin; hypertension; left ventricular hypertrophy
About this articleTitle
Role of aldosterone and bradykinin in pathogenesis of left ventricular hypertrophy in patients with primary hypertension
Journal
Issue
Article type
Original paper
Pages
223-231
Published online
2007-05-31
Page views
539
Article views/downloads
1022
Bibliographic record
Nadciśnienie tętnicze 2007;11(3):223-231.
Keywords
aldosterone
bradykinin
hypertension
left ventricular hypertrophy
Authors
Wojciech Tanecki
Wojciech Kosmala
Adam Spring
Maria Witkowska