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Vol 11, No 3 (2007)
Prace oryginalne
Published online: 2007-05-31
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Evaluation of plasma adiponectine concentration in relation to selected cardiovascular risk factors in patients with essential hypertension

Iwona Cendrowska-Demkow, Andrzej Januszewicz, Aleksander Prejbisz, Barbara Pręgowska-Chwała, Marek Kabat, Bogna Puciłowska-Jankowska, Jadwiga Janas, Piotr Hoffman, Beata Kuśmierczyk-Droszcz, Magdalena Januszewicz, Ilona Michałowska, Tomasz Zieliński, Mariola Pęczkowska, Zofia Dzielińska
Nadciśnienie tętnicze 2007;11(3):205-214.

open access

Vol 11, No 3 (2007)
Prace oryginalne
Published online: 2007-05-31

Abstract


Background Clinical trials have shown that adiponectin levels were significantly decreased in patients with severe hypertension, insulin resistance and other cardiovascular disorders eg coronary artery disease. The objective of our study was to evaluate the role of adiponectin in mild and moderate hypertension, and to estimate its relationship with metabolic risk factors in hypertensive patients.
Material and methods The study included 2 groups. Group 1 consisted of 54 untreated persons aged 38 ± 8.5, with mild to moderate essential hypertension; group 2 - 53 healthy subjects aged 38 ± 9.5 with normal blood pressure. Patients with obesity, severe hypertension, organ damage due to hypertension and with other cardiovascular disorders were not included. In both groups antropometric (BMI, body mass index, waist circumference) and biochemical parametres including plasma adiponectin concentration were evaluated. ABPM, echocardiography and renal arteries ultrasound examination were also performed.
Results There was no significant difference in concentration of adiponectin in plasma beetwen hypertensive patients (6.7 ± 3.79 µg/ml) and control group (5.7 ± 2.95 µg/ml). Both hypertensive and normotensive women were characterized by higher plasma adiponectin concentration as compared with respectively hypertensive and normotensive men. In both groups positive correlation between adiponectine and concentration of HDL-cholesterol (p < 0.0001; r = 0.56) was found. In both groups negative correlations between adiponectine plasma concentration and BMI, waist circumference, creatinine and triglicerides concentrations were also found.
Conclusions In our study there was no significant difference between plasma adiponectin concentration. These data may suggest relationship between plasma adiponectin concentration and the development of metabolic abnormalities in patients with mild to moderate hypertension without organ damage or concomitant cardiovascular diseases and metabolic syndrome.

Abstract


Background Clinical trials have shown that adiponectin levels were significantly decreased in patients with severe hypertension, insulin resistance and other cardiovascular disorders eg coronary artery disease. The objective of our study was to evaluate the role of adiponectin in mild and moderate hypertension, and to estimate its relationship with metabolic risk factors in hypertensive patients.
Material and methods The study included 2 groups. Group 1 consisted of 54 untreated persons aged 38 ± 8.5, with mild to moderate essential hypertension; group 2 - 53 healthy subjects aged 38 ± 9.5 with normal blood pressure. Patients with obesity, severe hypertension, organ damage due to hypertension and with other cardiovascular disorders were not included. In both groups antropometric (BMI, body mass index, waist circumference) and biochemical parametres including plasma adiponectin concentration were evaluated. ABPM, echocardiography and renal arteries ultrasound examination were also performed.
Results There was no significant difference in concentration of adiponectin in plasma beetwen hypertensive patients (6.7 ± 3.79 µg/ml) and control group (5.7 ± 2.95 µg/ml). Both hypertensive and normotensive women were characterized by higher plasma adiponectin concentration as compared with respectively hypertensive and normotensive men. In both groups positive correlation between adiponectine and concentration of HDL-cholesterol (p < 0.0001; r = 0.56) was found. In both groups negative correlations between adiponectine plasma concentration and BMI, waist circumference, creatinine and triglicerides concentrations were also found.
Conclusions In our study there was no significant difference between plasma adiponectin concentration. These data may suggest relationship between plasma adiponectin concentration and the development of metabolic abnormalities in patients with mild to moderate hypertension without organ damage or concomitant cardiovascular diseases and metabolic syndrome.
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Keywords

hypertension; adiponectine; cardiovascular risk factors

About this article
Title

Evaluation of plasma adiponectine concentration in relation to selected cardiovascular risk factors in patients with essential hypertension

Journal

Arterial Hypertension

Issue

Vol 11, No 3 (2007)

Pages

205-214

Published online

2007-05-31

Bibliographic record

Nadciśnienie tętnicze 2007;11(3):205-214.

Keywords

hypertension
adiponectine
cardiovascular risk factors

Authors

Iwona Cendrowska-Demkow
Andrzej Januszewicz
Aleksander Prejbisz
Barbara Pręgowska-Chwała
Marek Kabat
Bogna Puciłowska-Jankowska
Jadwiga Janas
Piotr Hoffman
Beata Kuśmierczyk-Droszcz
Magdalena Januszewicz
Ilona Michałowska
Tomasz Zieliński
Mariola Pęczkowska
Zofia Dzielińska

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