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Vol 11, No 5 (2007)
REVIEV
Published online: 2007-10-03
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Diuretics’ influence on blood vessels - have we got new arguments promoting administration of diuretics in arterial hypertension?

Hanna Kara-Perz, Teresa Kosicka, Jerzy Głuszek, Stanisław Perz
Nadciśnienie tętnicze 2007;11(5):428-434.

open access

Vol 11, No 5 (2007)
REVIEV
Published online: 2007-10-03

Abstract

Action of many antihypertensive drugs (i.e. angiotensin-converting enzyme inhibitors - ACE-I, calcium antagonists -A-Ca2+) concerning their influence on the wall of blood vessels is relatively well known, but diuretics’ activity as for blood vessels is currently still investigated. The aim of the present study was investigation of direct and indirect mechanisms of diuretics’ influence on the wall of blood vessels, especially regarding treatment of essential arterial hypertension (HA). Different groups of diuretics (loop diuretics, thiazide-like diuretics, aldosterone receptor antagonists and inhibitor of epithelial sodium channel) were analysed as for following mechanisms: 1. Effects mediated by calcium ions, 2. Influence on renin-angiotensin-aldosterone system (RAAS), 3. Influence on endothelin-1 concentration, 4. Effect on nitric oxide (NO), 5. Influence on natriuretic peptides (ANP, BNP), 6. Diuretics and immune/inflammatory processes associated with endothelium, 7. Effect on coagulation processes, 8. Influence on lipid and glucose profile.
Arterial Hypertension 2007, vol. 11, no 5, pages 428-434.

Abstract

Action of many antihypertensive drugs (i.e. angiotensin-converting enzyme inhibitors - ACE-I, calcium antagonists -A-Ca2+) concerning their influence on the wall of blood vessels is relatively well known, but diuretics’ activity as for blood vessels is currently still investigated. The aim of the present study was investigation of direct and indirect mechanisms of diuretics’ influence on the wall of blood vessels, especially regarding treatment of essential arterial hypertension (HA). Different groups of diuretics (loop diuretics, thiazide-like diuretics, aldosterone receptor antagonists and inhibitor of epithelial sodium channel) were analysed as for following mechanisms: 1. Effects mediated by calcium ions, 2. Influence on renin-angiotensin-aldosterone system (RAAS), 3. Influence on endothelin-1 concentration, 4. Effect on nitric oxide (NO), 5. Influence on natriuretic peptides (ANP, BNP), 6. Diuretics and immune/inflammatory processes associated with endothelium, 7. Effect on coagulation processes, 8. Influence on lipid and glucose profile.
Arterial Hypertension 2007, vol. 11, no 5, pages 428-434.
Get Citation

Keywords

diuretics; arterial hypertension; blood vessels' wall

About this article
Title

Diuretics’ influence on blood vessels - have we got new arguments promoting administration of diuretics in arterial hypertension?

Journal

Arterial Hypertension

Issue

Vol 11, No 5 (2007)

Pages

428-434

Published online

2007-10-03

Bibliographic record

Nadciśnienie tętnicze 2007;11(5):428-434.

Keywords

diuretics
arterial hypertension
blood vessels' wall

Authors

Hanna Kara-Perz
Teresa Kosicka
Jerzy Głuszek
Stanisław Perz

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