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The influence of contrast medium used during coronary angiography procedure on nitrite/nitrate and endothelin-1 levels in blood of patients with arterial hypertension
open access
Abstract
Material and methods Studies were carried out in 72 patients (58 men and 14 women, mean age: 57.4 ± 10.7 years) with arterial hypertension. In all patients coronary angiography with the use of non-ionic contrast medium was performed due to symptoms of coronary heart disease. Prophylactic therapy of intravenous hydration with 0.9% NaCl and acetylcysteine prior to and after coronary angiography was used. Serum creatinine level before and early after coronarography was measured. Endothelial function wasestimated by concentrations endothelin-1 and indirectly nitric oxide by measurement of nitrite/nitrate in blood before and then one and six hours after the invasive procedure.
Results Serum creatinine level as well as endothelin-1 in plasma did not change significantly after the examination. Serum nitric oxide concentration was significantly lower after coronary angiography after one and after six hours in comparison with measurements before the invasive procedure (p < 0.01).
Conclusions Performed studies show that the use of contrast media during coronary angiography may decrease level of nitrite/nitrate causing endothelial dysfunction. Preventive therapy with hydration and orally administered acetylcysteine before and after coronary angiography may be an effective protective strategy, even though the decrease in nitrite/nitrate level is detected.
Arterial Hypertension 2007, vol. 11, no 5, pages 406-411.
Abstract
Material and methods Studies were carried out in 72 patients (58 men and 14 women, mean age: 57.4 ± 10.7 years) with arterial hypertension. In all patients coronary angiography with the use of non-ionic contrast medium was performed due to symptoms of coronary heart disease. Prophylactic therapy of intravenous hydration with 0.9% NaCl and acetylcysteine prior to and after coronary angiography was used. Serum creatinine level before and early after coronarography was measured. Endothelial function wasestimated by concentrations endothelin-1 and indirectly nitric oxide by measurement of nitrite/nitrate in blood before and then one and six hours after the invasive procedure.
Results Serum creatinine level as well as endothelin-1 in plasma did not change significantly after the examination. Serum nitric oxide concentration was significantly lower after coronary angiography after one and after six hours in comparison with measurements before the invasive procedure (p < 0.01).
Conclusions Performed studies show that the use of contrast media during coronary angiography may decrease level of nitrite/nitrate causing endothelial dysfunction. Preventive therapy with hydration and orally administered acetylcysteine before and after coronary angiography may be an effective protective strategy, even though the decrease in nitrite/nitrate level is detected.
Arterial Hypertension 2007, vol. 11, no 5, pages 406-411.
Keywords
contrast nephropathy; nitrite/nitrate; endothelin-1; arterial hypertension; iodine contrast media
Title
The influence of contrast medium used during coronary angiography procedure on nitrite/nitrate and endothelin-1 levels in blood of patients with arterial hypertension
Journal
Issue
Article type
Original paper
Pages
406-411
Published online
2007-10-03
Page views
658
Article views/downloads
3733
Bibliographic record
Nadciśnienie tętnicze 2007;11(5):406-411.
Keywords
contrast nephropathy
nitrite/nitrate
endothelin-1
arterial hypertension
iodine contrast media
Authors
Arkadiusz Derkacz
Rafał Poręba
Małgorzata Poręba
Marcin Protasiewicz
Ryszard Andrzejak