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Vol 11, No 5 (2007)
Prace oryginalne
Published online: 2007-10-03
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The influence of contrast medium used during coronary angiography procedure on nitrite/nitrate and endothelin-1 levels in blood of patients with arterial hypertension

Arkadiusz Derkacz, Rafał Poręba, Małgorzata Poręba, Marcin Protasiewicz, Ryszard Andrzejak
Nadciśnienie tętnicze 2007;11(5):406-411.

open access

Vol 11, No 5 (2007)
Prace oryginalne
Published online: 2007-10-03

Abstract

Background Mechanisms underlying manifestation of contrast-induced nephropathy (CIN) are still not clear. Endothelial dysfunction present in patients with arterial hypertension may probably be one of the factors. The aim of the study was to determine the influence of contrast medium used during coronary angiography on creatinine serum level and two parameters connected with endothelial function such as nitric oxide (NO) measured indirectly by nitrite/nitrate concentration and endothelin-1 (ET-1) in patients with arterial hypertension in whom some protective strategies against contrast-induced nephropathy were used.
Material and methods Studies were carried out in 72 patients (58 men and 14 women, mean age: 57.4 ± 10.7 years) with arterial hypertension. In all patients coronary angiography with the use of non-ionic contrast medium was performed due to symptoms of coronary heart disease. Prophylactic therapy of intravenous hydration with 0.9% NaCl and acetylcysteine prior to and after coronary angiography was used. Serum creatinine level before and early after coronarography was measured. Endothelial function wasestimated by concentrations endothelin-1 and indirectly nitric oxide by measurement of nitrite/nitrate in blood before and then one and six hours after the invasive procedure.
Results Serum creatinine level as well as endothelin-1 in plasma did not change significantly after the examination. Serum nitric oxide concentration was significantly lower after coronary angiography after one and after six hours in comparison with measurements before the invasive procedure (p < 0.01).
Conclusions Performed studies show that the use of contrast media during coronary angiography may decrease level of nitrite/nitrate causing endothelial dysfunction. Preventive therapy with hydration and orally administered acetylcysteine before and after coronary angiography may be an effective protective strategy, even though the decrease in nitrite/nitrate level is detected.
Arterial Hypertension 2007, vol. 11, no 5, pages 406-411.

Abstract

Background Mechanisms underlying manifestation of contrast-induced nephropathy (CIN) are still not clear. Endothelial dysfunction present in patients with arterial hypertension may probably be one of the factors. The aim of the study was to determine the influence of contrast medium used during coronary angiography on creatinine serum level and two parameters connected with endothelial function such as nitric oxide (NO) measured indirectly by nitrite/nitrate concentration and endothelin-1 (ET-1) in patients with arterial hypertension in whom some protective strategies against contrast-induced nephropathy were used.
Material and methods Studies were carried out in 72 patients (58 men and 14 women, mean age: 57.4 ± 10.7 years) with arterial hypertension. In all patients coronary angiography with the use of non-ionic contrast medium was performed due to symptoms of coronary heart disease. Prophylactic therapy of intravenous hydration with 0.9% NaCl and acetylcysteine prior to and after coronary angiography was used. Serum creatinine level before and early after coronarography was measured. Endothelial function wasestimated by concentrations endothelin-1 and indirectly nitric oxide by measurement of nitrite/nitrate in blood before and then one and six hours after the invasive procedure.
Results Serum creatinine level as well as endothelin-1 in plasma did not change significantly after the examination. Serum nitric oxide concentration was significantly lower after coronary angiography after one and after six hours in comparison with measurements before the invasive procedure (p < 0.01).
Conclusions Performed studies show that the use of contrast media during coronary angiography may decrease level of nitrite/nitrate causing endothelial dysfunction. Preventive therapy with hydration and orally administered acetylcysteine before and after coronary angiography may be an effective protective strategy, even though the decrease in nitrite/nitrate level is detected.
Arterial Hypertension 2007, vol. 11, no 5, pages 406-411.
Get Citation

Keywords

contrast nephropathy; nitrite/nitrate; endothelin-1; arterial hypertension; iodine contrast media

About this article
Title

The influence of contrast medium used during coronary angiography procedure on nitrite/nitrate and endothelin-1 levels in blood of patients with arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 11, No 5 (2007)

Pages

406-411

Published online

2007-10-03

Bibliographic record

Nadciśnienie tętnicze 2007;11(5):406-411.

Keywords

contrast nephropathy
nitrite/nitrate
endothelin-1
arterial hypertension
iodine contrast media

Authors

Arkadiusz Derkacz
Rafał Poręba
Małgorzata Poręba
Marcin Protasiewicz
Ryszard Andrzejak

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