Vol 11, No 5 (2007)
Original paper
Published online: 2007-10-03
Relation of CYP11B2 C-344T and a adducin Gly460Trp polymorphisms with blood pressure variability
Nadciśnienie tętnicze 2007;11(5):395-405.
Abstract
Background CYP11B2 and a adducin are candidate genes
for hypertension.
We investigated the possible association between circadian
changes in blood pressure and the CYP11B2 C-344T polymorphism
and a adducin Gly460Trp polymorphism.
Material and methods We randomly recruited 83 nuclear families (294 subjects) from the population of Cracow. SpaceLab 90207 monitors were programmed to obtain BP readings every 15 min. during daytime and every 30 min. at night (0-6 AM). The nocturnal BP fall was the difference between mean day (8 am-10 pm) and night (0-6 am) BP values, expressed as a percentage of daytime BP value. We explored the phenotype-genotype associations by means of generalized estimating equations and the quantitative transmission disequillibrium test (QTDT).
Results Carriers of -344C allele had higher systolic and diastolic blood pressure at night and a smaller nocturnal SBP and DBP fall. Moreover among offspring, carriers of -344C allele had higher SBP during the entire 24 hours as compared to TT homozygotes. In QTDT analyses, the association between the nocturnal BP fall and transmission of the CYP11B2 -344Callele did not reach signifisignificance. There was no significant relationship between blood pressure and the Gly460Trp polymorphism of a adducin gene. There was a significant interaction between the C-344T polymorphism of CYP11B2 gene and excreted sodium in determining blood pressure phenotypes.
Conclusions These results suggest that C-344T polymorphism of CYP11B2 might influence blood pressure at night and the circadian BP profile. This effect of the CYP11B2 polymorphism occurred in subjects with a higher than median urinary sodium excretion. Arterial Hypertension 2007, vol. 11, no 5, pages 395-405.
Material and methods We randomly recruited 83 nuclear families (294 subjects) from the population of Cracow. SpaceLab 90207 monitors were programmed to obtain BP readings every 15 min. during daytime and every 30 min. at night (0-6 AM). The nocturnal BP fall was the difference between mean day (8 am-10 pm) and night (0-6 am) BP values, expressed as a percentage of daytime BP value. We explored the phenotype-genotype associations by means of generalized estimating equations and the quantitative transmission disequillibrium test (QTDT).
Results Carriers of -344C allele had higher systolic and diastolic blood pressure at night and a smaller nocturnal SBP and DBP fall. Moreover among offspring, carriers of -344C allele had higher SBP during the entire 24 hours as compared to TT homozygotes. In QTDT analyses, the association between the nocturnal BP fall and transmission of the CYP11B2 -344Callele did not reach signifisignificance. There was no significant relationship between blood pressure and the Gly460Trp polymorphism of a adducin gene. There was a significant interaction between the C-344T polymorphism of CYP11B2 gene and excreted sodium in determining blood pressure phenotypes.
Conclusions These results suggest that C-344T polymorphism of CYP11B2 might influence blood pressure at night and the circadian BP profile. This effect of the CYP11B2 polymorphism occurred in subjects with a higher than median urinary sodium excretion. Arterial Hypertension 2007, vol. 11, no 5, pages 395-405.
Keywords: aldosterone synthasea adducingeneticsblood pressure variability