open access
The role of spontaneous baroreflex sensitivity in predicting late atrial fibrillation recurrence
open access
Abstract
Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation.
Material and methods The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up.
Results During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg,p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history.
Conclusions Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.
Arterial Hypertension 2007, vol. 11, no 6, pages 483-497.
Abstract
Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation.
Material and methods The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up.
Results During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg,p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history.
Conclusions Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.
Arterial Hypertension 2007, vol. 11, no 6, pages 483-497.
Keywords
atrial fibrillation; baroreflex sensitivity; autonomic nervous system
Title
The role of spontaneous baroreflex sensitivity in predicting late atrial fibrillation recurrence
Journal
Issue
Article type
Original paper
Pages
483-497
Published online
2007-10-09
Page views
704
Article views/downloads
1835
Bibliographic record
Nadciśnienie tętnicze 2007;11(6):483-497.
Keywords
atrial fibrillation
baroreflex sensitivity
autonomic nervous system
Authors
Katarzyna Styczkiewicz
Mario Facchini
Giovanni Battista Perego
Grzegorz Bilo
Danuta Czarnecka
Kalina Kawecka-Jaszcz
Gianfranco Parati