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Short-term efficacy of telmisartan in antihypertensive treatment in 6985 patients
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Abstract
Material and methods Average age of 6985 patients (49.5% men) was 56.3 (± 12.1) years. Baseline office blood pressure averaged 161/95 (± 13/8) mm Hg, and baseline self-measured blood pressure averaged 158/94 (± 14/8) mm Hg. Percentage of self-measurements exceeding 130/85 mm Hg was 46 in the morning and 43 in the evening. Average dose of telmisartan was 50.3 (± 17.6) mg, and 23.7% of patients received hydrochlorothiazide.
Results Office blood pressure fell by 23/11 mm Hg (systolic/diastolic), and self-measured by 28/14 mm Hg (p < 0.0001). The percentage of morning and evening self-measured blood pressures exceeding the threshold fell to 13 and 9, respectively. In the stratified analyses, sex and age did not differentiate the antihypertensive response. The effect was not inferior in patients with complicated hypertension, smokers, diabetics, and obese subjects. The effect was proportional to level of baseline blood pressure (p < 0.0001). In two patients we observed transient elevation of renal function parameters which required drug withdrawal.
Conclusion In conclusion, in nine-week observation, telmisartan proved to be an effective and safe antihypertensive medication.
Abstract
Material and methods Average age of 6985 patients (49.5% men) was 56.3 (± 12.1) years. Baseline office blood pressure averaged 161/95 (± 13/8) mm Hg, and baseline self-measured blood pressure averaged 158/94 (± 14/8) mm Hg. Percentage of self-measurements exceeding 130/85 mm Hg was 46 in the morning and 43 in the evening. Average dose of telmisartan was 50.3 (± 17.6) mg, and 23.7% of patients received hydrochlorothiazide.
Results Office blood pressure fell by 23/11 mm Hg (systolic/diastolic), and self-measured by 28/14 mm Hg (p < 0.0001). The percentage of morning and evening self-measured blood pressures exceeding the threshold fell to 13 and 9, respectively. In the stratified analyses, sex and age did not differentiate the antihypertensive response. The effect was not inferior in patients with complicated hypertension, smokers, diabetics, and obese subjects. The effect was proportional to level of baseline blood pressure (p < 0.0001). In two patients we observed transient elevation of renal function parameters which required drug withdrawal.
Conclusion In conclusion, in nine-week observation, telmisartan proved to be an effective and safe antihypertensive medication.
Keywords
hypertension; antihypertensive treatment; telmisartan; home blood pressure measurement
Title
Short-term efficacy of telmisartan in antihypertensive treatment in 6985 patients
Journal
Issue
Article type
Original paper
Pages
12-19
Published online
2008-01-28
Page views
544
Article views/downloads
2029
Bibliographic record
Nadciśnienie tętnicze 2008;12(1):12-19.
Keywords
hypertension
antihypertensive treatment
telmisartan
home blood pressure measurement
Authors
Jerzy Gąsowski
Barbara Wizner
Tomasz Grodzicki