open access

Vol 12, No 2 (2008)
REVIEV
Published online: 2008-04-03
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Urinary protein excretion in evaluation of renal impairment progression in hypertension

Barbara Lisowska-Myjak, Anna Koper, Jan Pachecka
Nadciśnienie tętnicze 2008;12(2):118-126.

open access

Vol 12, No 2 (2008)
REVIEV
Published online: 2008-04-03

Abstract

Renal impairment due to arterial hypertension is a wellknown clinical phenomenon. Initiation and course of some progressive renal diseases in hypertension may depend both on mechanical factors, and on cellular and inflammatory mechanisms. Increase in urinary excretion of protein is an independent marker of glomerular damage and at the same time a pathogenic factor - a mediator of progressive damage to renal tubules and parenchyma. Measurement of total urinary protein seems to be of lesser diagnostic and prognostic significance than the evaluation of individual proteins. Characteristic features of these proteins (size and charge of a particle), their origin (plasma or nephrons), and functions (involvement in inflammatory reaction) may be specific for an anatomical localization, stage and activity of renal impairment in course of arterial hypertension.

Abstract

Renal impairment due to arterial hypertension is a wellknown clinical phenomenon. Initiation and course of some progressive renal diseases in hypertension may depend both on mechanical factors, and on cellular and inflammatory mechanisms. Increase in urinary excretion of protein is an independent marker of glomerular damage and at the same time a pathogenic factor - a mediator of progressive damage to renal tubules and parenchyma. Measurement of total urinary protein seems to be of lesser diagnostic and prognostic significance than the evaluation of individual proteins. Characteristic features of these proteins (size and charge of a particle), their origin (plasma or nephrons), and functions (involvement in inflammatory reaction) may be specific for an anatomical localization, stage and activity of renal impairment in course of arterial hypertension.
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Keywords

hypertension; urine; chronic kidney failure; proteinuria; urine proteins; microalbuminuria; inflammation

About this article
Title

Urinary protein excretion in evaluation of renal impairment progression in hypertension

Journal

Arterial Hypertension

Issue

Vol 12, No 2 (2008)

Pages

118-126

Published online

2008-04-03

Bibliographic record

Nadciśnienie tętnicze 2008;12(2):118-126.

Keywords

hypertension
urine
chronic kidney failure
proteinuria
urine proteins
microalbuminuria
inflammation

Authors

Barbara Lisowska-Myjak
Anna Koper
Jan Pachecka

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