Vol 12, No 3 (2008)
Review paper
Published online: 2008-05-29
Endothelial dysfunction and ADMA in pathogenesis of arterial hypertension
Adrian Doroszko, Ryszard Andrzejak, Andrzej Szuba
Nadciśnienie tętnicze 2008;12(3):224-237.
Vol 12, No 3 (2008)
REVIEV
Published online: 2008-05-29
Abstract
Cardiovascular diseases (CVD) are today one of the major
healthcare problems of the world population. Endothelial
dysfunction (ED) reflects prominent abnormalities observed
in these disorders. Nitric oxide is one of the most
potent endothelial vasodilators and has also anti-inflammatory
and antithrombotic properties. NO-mediated endothelium
- dependent vasodilatation plays a crucial role
in regulation of vascular tone. Impaired activity of NO-dependent metabolic pathways in endothelium may increase
the risk of CVD and may be an important pathophysiological
link leading to development of arterial hypertension
(HTA). Asymmetric dimethylarginine
(ADMA) is an endogenous inhibitor of NO synthase,
which may cause ED due to decreased NO-availability.
ADMA may be not only a marker, but also an active mediator
in pathogenesis of CVD. Its levels have been shown to
be elevated in variety of disorders, e.g. in hypertension. This
article gives a brief review of contemporary state of knowledge
regarding ED, ADMA and HTA. Pathophysiology of
ED and HTA and possible pharmacological interventions
aiming the modulation of ADMA level are discussed.
Abstract
Cardiovascular diseases (CVD) are today one of the major
healthcare problems of the world population. Endothelial
dysfunction (ED) reflects prominent abnormalities observed
in these disorders. Nitric oxide is one of the most
potent endothelial vasodilators and has also anti-inflammatory
and antithrombotic properties. NO-mediated endothelium
- dependent vasodilatation plays a crucial role
in regulation of vascular tone. Impaired activity of NO-dependent metabolic pathways in endothelium may increase
the risk of CVD and may be an important pathophysiological
link leading to development of arterial hypertension
(HTA). Asymmetric dimethylarginine
(ADMA) is an endogenous inhibitor of NO synthase,
which may cause ED due to decreased NO-availability.
ADMA may be not only a marker, but also an active mediator
in pathogenesis of CVD. Its levels have been shown to
be elevated in variety of disorders, e.g. in hypertension. This
article gives a brief review of contemporary state of knowledge
regarding ED, ADMA and HTA. Pathophysiology of
ED and HTA and possible pharmacological interventions
aiming the modulation of ADMA level are discussed.
Keywords
endothelial dysfunction; ADMA; arterial hypertension
Title
Endothelial dysfunction and ADMA in pathogenesis of arterial hypertension
Journal
Arterial Hypertension
Issue
Vol 12, No 3 (2008)
Article type
Review paper
Pages
224-237
Published online
2008-05-29
Page views
1396
Article views/downloads
3414
Bibliographic record
Nadciśnienie tętnicze 2008;12(3):224-237.
Keywords
endothelial dysfunction
ADMA
arterial hypertension
Authors
Adrian Doroszko
Ryszard Andrzejak
Andrzej Szuba