open access

Vol 12, No 4 (2008)
REVIEV
Published online: 2008-09-01
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Neoplasm and arterial hypertension - do any correlations exist?

Hanna Kara-Perz, Teresa Kosicka, Jerzy Głuszek
Nadciśnienie tętnicze 2008;12(4):309-315.

open access

Vol 12, No 4 (2008)
REVIEV
Published online: 2008-09-01

Abstract

In this paper we collected the results of the recent investigations concerning the main connections between arterial hypertension and cancer. Lately there has been a great interest concerning frequent occurrence of hypertension as a result of antineoplastic medication with angiogenesis inhibitors. Pathogenetic mechanism leading to blood pressure elevation may be connected with vascular rarefaction, reduced nitric oxide synthesis and vascular constriction.
The next problem is a role of hypertension as a cancer promoting factor. Many researchers observed correlation between hypertension and cancer risk. The others did not prove this finding.
The third question is whether antihypertensive therapy could be a risk factor of cancer.
The majority of investigations denies this association between antihypertensive drugs and an increased cancer risk, nevertheless diuretics probably may increase cancer risk, while ACE-inhibitors seem to have a small protective effect.

Abstract

In this paper we collected the results of the recent investigations concerning the main connections between arterial hypertension and cancer. Lately there has been a great interest concerning frequent occurrence of hypertension as a result of antineoplastic medication with angiogenesis inhibitors. Pathogenetic mechanism leading to blood pressure elevation may be connected with vascular rarefaction, reduced nitric oxide synthesis and vascular constriction.
The next problem is a role of hypertension as a cancer promoting factor. Many researchers observed correlation between hypertension and cancer risk. The others did not prove this finding.
The third question is whether antihypertensive therapy could be a risk factor of cancer.
The majority of investigations denies this association between antihypertensive drugs and an increased cancer risk, nevertheless diuretics probably may increase cancer risk, while ACE-inhibitors seem to have a small protective effect.
Get Citation

Keywords

arterial hypertension; neoplasm; angiogenesis inhibitors

About this article
Title

Neoplasm and arterial hypertension - do any correlations exist?

Journal

Arterial Hypertension

Issue

Vol 12, No 4 (2008)

Pages

309-315

Published online

2008-09-01

Bibliographic record

Nadciśnienie tętnicze 2008;12(4):309-315.

Keywords

arterial hypertension
neoplasm
angiogenesis inhibitors

Authors

Hanna Kara-Perz
Teresa Kosicka
Jerzy Głuszek

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