open access

Vol 12, No 4 (2008)
Prace oryginalne
Published online: 2008-09-01
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Brain natriuretic peptide in women with mild hypertension in perimenopausal period

Kalina Kawecka-Jaszcz, Aneta Pośnik-Urbańska, Danuta Czarnecka, Władysława Kolasińska-Kloch, Danuta Fedak, Wiktoria Wojciechowska
Nadciśnienie tętnicze 2008;12(4):261-268.

open access

Vol 12, No 4 (2008)
Prace oryginalne
Published online: 2008-09-01

Abstract

Background Morbidity and mortality from cardiovascular diseases increase rapidly in women after menopause. Relationship between menopause and hypertension has been a topic of investigation for several years. There are no evidences about the influence of menopause on brain natriuretic peptide level. Present studies indicate the important prognostic value of this parameter in this group of patients. The aim of this study was to assess the level of N-terminal part of brain natriuretic peptide as well as the correlation of this factor with values of blood pressure in hypertensive women in relation to post- and premenopausal hormonal status.
Material and methods The study included 112 women aged 45 to 55 years (mean age 50.73 ± 1.82 years) with mild essential hypertension confirmed by conventional blood pressure measurements and 24 h ABP monitoring (SpaceLabs 90207). The study population was stratified according to hormonal status: postmenopausal (group A; n = 61; age 51.03 ± 1.39 years) and premenopausal (group B; n = 51; age 50.37 ± 2.19 years). Fasting plasma level of NT-proBNP, was measured by immunochemical method.
Results The level of NT-proBNP was significantly higher in women after menopause (1.88 ± 0.27 [75.86] vs. 1.75 ± 0.28 [56.23] log pg/ml; p = 0.016), in the whole group 1.82 ± 0.28 (66.07) log pg/ml.
Conclusions The women after menopause are characterized by higher level of NT-proBNP than premenopausal ones. Furthure investigations are required to explain this phenomenon.

Abstract

Background Morbidity and mortality from cardiovascular diseases increase rapidly in women after menopause. Relationship between menopause and hypertension has been a topic of investigation for several years. There are no evidences about the influence of menopause on brain natriuretic peptide level. Present studies indicate the important prognostic value of this parameter in this group of patients. The aim of this study was to assess the level of N-terminal part of brain natriuretic peptide as well as the correlation of this factor with values of blood pressure in hypertensive women in relation to post- and premenopausal hormonal status.
Material and methods The study included 112 women aged 45 to 55 years (mean age 50.73 ± 1.82 years) with mild essential hypertension confirmed by conventional blood pressure measurements and 24 h ABP monitoring (SpaceLabs 90207). The study population was stratified according to hormonal status: postmenopausal (group A; n = 61; age 51.03 ± 1.39 years) and premenopausal (group B; n = 51; age 50.37 ± 2.19 years). Fasting plasma level of NT-proBNP, was measured by immunochemical method.
Results The level of NT-proBNP was significantly higher in women after menopause (1.88 ± 0.27 [75.86] vs. 1.75 ± 0.28 [56.23] log pg/ml; p = 0.016), in the whole group 1.82 ± 0.28 (66.07) log pg/ml.
Conclusions The women after menopause are characterized by higher level of NT-proBNP than premenopausal ones. Furthure investigations are required to explain this phenomenon.
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Keywords

hypertension; NT-proBNP; menopause; women

About this article
Title

Brain natriuretic peptide in women with mild hypertension in perimenopausal period

Journal

Arterial Hypertension

Issue

Vol 12, No 4 (2008)

Pages

261-268

Published online

2008-09-01

Bibliographic record

Nadciśnienie tętnicze 2008;12(4):261-268.

Keywords

hypertension
NT-proBNP
menopause
women

Authors

Kalina Kawecka-Jaszcz
Aneta Pośnik-Urbańska
Danuta Czarnecka
Władysława Kolasińska-Kloch
Danuta Fedak
Wiktoria Wojciechowska

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