Vol 12, No 4 (2008)
Editorial
Published online: 2008-09-01
PTH and arterial hypertension
Anna Bożek, Magdalena Pajda, Jerzy Chudek, Andrzej Więcek
Nadciśnienie tętnicze 2008;12(4):253-260.
Vol 12, No 4 (2008)
Artykuły redakcyjne
Published online: 2008-09-01
Abstract
Parathormon (PTH) has been recognized as a potential
factor in the etiopathogenesis of essential hypertension.
The higher prevalence of arterial hypertention in primary
hyperparathyroidism (pHPT) than in the general population
and higher serum PTH concetration in patients
with essential hypertensive are the only indirect evidence
confirming this assumption. Infusion of PTH in
man results in transient vasodilatation and increased
urinary sodium excretion that gives evidence against its
hypertensive effect. On the contrary, impaired endothelial
function, proliferation of vascular smooth cells and
heart hypertrophy may cause increase of blood pressure.
Question concerning the role of PTH in the
pathogenesis of arterial hypertension arises when excretory
renal function, which is often impaired not only in
patients with pHPT but also with arterial hypertension
as a result of hypertensive nephropathy and ageing, is
taken under consideration. It is important to remember
about the negative consequences of long-term kidney
exposition to increased PTH and serum calcium level
in patients with pHPT. However, the role of PTH in
the etiopathogenesis of arterial hypertension is still unclear,
pHPT is undoubtedly associated with increased
cardiovascular risk.
The aim of this critical review is to summarize current
arguments concerning the relationship between PTH and
arterial hypertension.
Abstract
Parathormon (PTH) has been recognized as a potential
factor in the etiopathogenesis of essential hypertension.
The higher prevalence of arterial hypertention in primary
hyperparathyroidism (pHPT) than in the general population
and higher serum PTH concetration in patients
with essential hypertensive are the only indirect evidence
confirming this assumption. Infusion of PTH in
man results in transient vasodilatation and increased
urinary sodium excretion that gives evidence against its
hypertensive effect. On the contrary, impaired endothelial
function, proliferation of vascular smooth cells and
heart hypertrophy may cause increase of blood pressure.
Question concerning the role of PTH in the
pathogenesis of arterial hypertension arises when excretory
renal function, which is often impaired not only in
patients with pHPT but also with arterial hypertension
as a result of hypertensive nephropathy and ageing, is
taken under consideration. It is important to remember
about the negative consequences of long-term kidney
exposition to increased PTH and serum calcium level
in patients with pHPT. However, the role of PTH in
the etiopathogenesis of arterial hypertension is still unclear,
pHPT is undoubtedly associated with increased
cardiovascular risk.
The aim of this critical review is to summarize current
arguments concerning the relationship between PTH and
arterial hypertension.
Keywords
parathormon; primary hyperparathyroidism; parathyreoidectomy; arterial hypertension
Title
PTH and arterial hypertension
Journal
Arterial Hypertension
Issue
Vol 12, No 4 (2008)
Article type
Editorial
Pages
253-260
Published online
2008-09-01
Page views
1154
Article views/downloads
7747
Bibliographic record
Nadciśnienie tętnicze 2008;12(4):253-260.
Keywords
parathormon
primary hyperparathyroidism
parathyreoidectomy
arterial hypertension
Authors
Anna Bożek
Magdalena Pajda
Jerzy Chudek
Andrzej Więcek