open access

Vol 12, No 5 (2008)
REVIEV
Published online: 2008-10-12
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Nephrosclerosis - are kidneys the victim of evolution?

Rafał Bednarski, Beata Jasińska, Paweł Stróżecki, Jacek Manitius
Nadciśnienie tętnicze 2008;12(5):382-388.

open access

Vol 12, No 5 (2008)
REVIEV
Published online: 2008-10-12

Abstract

The term “nephrosclerosis” literally means “hardening of kidney”, and is a reflection of a particular histopathological state. Pathological changes in arcuate arteries and interlobular arteries in the form of hyalinosis and hypertrophy of vasal muscular coat are specific to nephrosclerosis. Vascular lesions can be accompanied by gromerular and tubulo-intestitial tissue alteration. The etiology of nephrosclerosis is not fully known, but genetic factors seem to play an important role. Nephroangiosclerosis changes occur independently of arterial hypertension, and possibly lead to its development. Interesting is the fact, that a yearlong decrease of gromerular filtration in nephrosclerotic patients is similar to those associated with aging process. It is possible, that nephrosclerosis, just as arterial hypertension, is a civilization disease which has emerged in the contemporary, rich in water and salt environment, and earlier simply did not occur.

Abstract

The term “nephrosclerosis” literally means “hardening of kidney”, and is a reflection of a particular histopathological state. Pathological changes in arcuate arteries and interlobular arteries in the form of hyalinosis and hypertrophy of vasal muscular coat are specific to nephrosclerosis. Vascular lesions can be accompanied by gromerular and tubulo-intestitial tissue alteration. The etiology of nephrosclerosis is not fully known, but genetic factors seem to play an important role. Nephroangiosclerosis changes occur independently of arterial hypertension, and possibly lead to its development. Interesting is the fact, that a yearlong decrease of gromerular filtration in nephrosclerotic patients is similar to those associated with aging process. It is possible, that nephrosclerosis, just as arterial hypertension, is a civilization disease which has emerged in the contemporary, rich in water and salt environment, and earlier simply did not occur.
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Keywords

nephrosclerosis; arterial hypertension; genes; evolution

About this article
Title

Nephrosclerosis - are kidneys the victim of evolution?

Journal

Arterial Hypertension

Issue

Vol 12, No 5 (2008)

Pages

382-388

Published online

2008-10-12

Bibliographic record

Nadciśnienie tętnicze 2008;12(5):382-388.

Keywords

nephrosclerosis
arterial hypertension
genes
evolution

Authors

Rafał Bednarski
Beata Jasińska
Paweł Stróżecki
Jacek Manitius

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