Background Adipose tissue is a place where many bioactive substances are synthetized. One of them is adiponectin, which more and more often comes close to be regarded as one of the cardiovascular risk factors. The aim of this paper was to estimate the concentrations of adiponectin and insulin, selected metabolic parameters, family history and anthropometric factors in young population with primary arterial hypertension.
Material and methods 33 young patients with essential arterial hypertension were included in this study. The control group consisted of 14 properly chosen healthy people. The anthropometric, blood pressure and heart rate measurements were taken. Serum concentrations of total cholesterol, lipoprotein fractions, adiponectin and insulin were assessed.
Results In group of patients with arterial hypertension compared to control group significantly higher values of systolic (140 ± 14 mm Hg vs. 113 ± 8 mm Hg) and diastolic (81 ± 8 mm Hg vs. 71 ± 7 mm Hg) blood pressure, body mass (89.7 ± 25.8 kg vs. 62.9 ± 12.7 kg) and BMI (27.5 ± 6.2 kg/m² vs. 22.1 ± 1.3 kg/m²) were found and increased values of triglycerides (1.6 ± ± 1.2 mmol/l vs. 0.8 ± 0.3 mmol/l) and insulin (42.4 ± ± 68.1 μIU/ml vs. 16.7 ± 14.6 μIU/ml) concentrations were stated. The concentration of adiponectin were significantly lower (14.0 ± 4.5 μg/ml vs. 18.2 ± 6.1 μg/ml) in patients with arterial hypertension. The positive family history of arterial hypertension occurred more frequently in examined group (78.8% vs. 35.7%). In examined group the important positive correlation between adiponectin and HDL-cholesterol concentrations were revealed as well as negative one between adiponectin and concentration of triglycerides, body mass and BMI.
Conclusions 1. Adiponectin could be treated as independent from risk factors biomarker of development of arterial hypertension. 2. Due to frequent coexistence with arterial hypertension and obesity low adiponectin concentration could play a role in their pathogenesis.