Vol 12, No 5 (2008)
Original paper
Published online: 2008-10-12
Relation between clinical and biochemical variables and uric acid in essential hypertension
Nadciśnienie tętnicze 2008;12(5):352-358.
Abstract
Background Hyperuricemia was shown to be associated
with high blood pressure and risk for cardiovascular disease
in large studies. However, it is not known if this relates
to a worse clinical and biochemical profile of
hypertensives with higher uric acid (UA) levels treated in
a specialized center.
Material and methods 119 consecutive patients with moderate (16%) and severe (84%) primary hypertension entered the study. UA, serum creatinine, lipids, C-reactive protein (CRP) and tumor necrosis factor (TNF-α) levels, carotid intima-media thickness (IMT), left ventricular mass index (LVMI), left ventricular diastolic function (IVRT) and the antihypertensive treatment were assessed.
Results In univariate analysis UA correlated with creatinine (r = 0,46, p < 0,001), waist-hip ratio (r = 0,45, p < 0,001), HDL cholesterol (r = –0,39, p < 0,001) and also isovolumetric relaxation time (IVRT), IMT, LVMI, CRP, TNF-α. In multiple regression analysis UA independently correlated only with waist-hip ratio, CRP and creatinine. The patients with UA in upper quartile (> 402 μmol/l) as compared to lower quartile had higher LVMI (by 36 g/m2), IMT (by 0,1 mm), prolonged IVRT (by 11 ms), higher CRP and triglicerides and lower HDL cholesterol levels and required more antihypertensive drugs for blood pressure control.
Conclusions Higher level of uric acid in hypertensives designates patients with worse clinical and biochemical profile including presence of other components of metabolic syndrome and subclinical target organ damage.
Material and methods 119 consecutive patients with moderate (16%) and severe (84%) primary hypertension entered the study. UA, serum creatinine, lipids, C-reactive protein (CRP) and tumor necrosis factor (TNF-α) levels, carotid intima-media thickness (IMT), left ventricular mass index (LVMI), left ventricular diastolic function (IVRT) and the antihypertensive treatment were assessed.
Results In univariate analysis UA correlated with creatinine (r = 0,46, p < 0,001), waist-hip ratio (r = 0,45, p < 0,001), HDL cholesterol (r = –0,39, p < 0,001) and also isovolumetric relaxation time (IVRT), IMT, LVMI, CRP, TNF-α. In multiple regression analysis UA independently correlated only with waist-hip ratio, CRP and creatinine. The patients with UA in upper quartile (> 402 μmol/l) as compared to lower quartile had higher LVMI (by 36 g/m2), IMT (by 0,1 mm), prolonged IVRT (by 11 ms), higher CRP and triglicerides and lower HDL cholesterol levels and required more antihypertensive drugs for blood pressure control.
Conclusions Higher level of uric acid in hypertensives designates patients with worse clinical and biochemical profile including presence of other components of metabolic syndrome and subclinical target organ damage.
Keywords: arterial hypertensionuric acidtarget organ damagechronic inflammation