open access
Relation between clinical and biochemical variables and uric acid in essential hypertension
open access
Abstract
Material and methods 119 consecutive patients with moderate (16%) and severe (84%) primary hypertension entered the study. UA, serum creatinine, lipids, C-reactive protein (CRP) and tumor necrosis factor (TNF-α) levels, carotid intima-media thickness (IMT), left ventricular mass index (LVMI), left ventricular diastolic function (IVRT) and the antihypertensive treatment were assessed.
Results In univariate analysis UA correlated with creatinine (r = 0,46, p < 0,001), waist-hip ratio (r = 0,45, p < 0,001), HDL cholesterol (r = –0,39, p < 0,001) and also isovolumetric relaxation time (IVRT), IMT, LVMI, CRP, TNF-α. In multiple regression analysis UA independently correlated only with waist-hip ratio, CRP and creatinine. The patients with UA in upper quartile (> 402 μmol/l) as compared to lower quartile had higher LVMI (by 36 g/m2), IMT (by 0,1 mm), prolonged IVRT (by 11 ms), higher CRP and triglicerides and lower HDL cholesterol levels and required more antihypertensive drugs for blood pressure control.
Conclusions Higher level of uric acid in hypertensives designates patients with worse clinical and biochemical profile including presence of other components of metabolic syndrome and subclinical target organ damage.
Abstract
Material and methods 119 consecutive patients with moderate (16%) and severe (84%) primary hypertension entered the study. UA, serum creatinine, lipids, C-reactive protein (CRP) and tumor necrosis factor (TNF-α) levels, carotid intima-media thickness (IMT), left ventricular mass index (LVMI), left ventricular diastolic function (IVRT) and the antihypertensive treatment were assessed.
Results In univariate analysis UA correlated with creatinine (r = 0,46, p < 0,001), waist-hip ratio (r = 0,45, p < 0,001), HDL cholesterol (r = –0,39, p < 0,001) and also isovolumetric relaxation time (IVRT), IMT, LVMI, CRP, TNF-α. In multiple regression analysis UA independently correlated only with waist-hip ratio, CRP and creatinine. The patients with UA in upper quartile (> 402 μmol/l) as compared to lower quartile had higher LVMI (by 36 g/m2), IMT (by 0,1 mm), prolonged IVRT (by 11 ms), higher CRP and triglicerides and lower HDL cholesterol levels and required more antihypertensive drugs for blood pressure control.
Conclusions Higher level of uric acid in hypertensives designates patients with worse clinical and biochemical profile including presence of other components of metabolic syndrome and subclinical target organ damage.
Keywords
arterial hypertension; uric acid; target organ damage; chronic inflammation
Title
Relation between clinical and biochemical variables and uric acid in essential hypertension
Journal
Issue
Article type
Original paper
Pages
352-358
Published online
2008-10-12
Page views
1191
Article views/downloads
5861
Bibliographic record
Nadciśnienie tętnicze 2008;12(5):352-358.
Keywords
arterial hypertension
uric acid
target organ damage
chronic inflammation
Authors
Marek Jastrzębski
Marek Klocek
Danuta Czarnecka
Kalina Kawecka-Jaszcz