Assessment of the relationship amongst the function and activity of the left ventricle and kidneys function, the uric acid and TGF-β, VEGF in patients with untreated hypertension

Abstract

Background Aim of the study was to evaluate the relationship among morphological and functional changes in the cardiovascular system and function of kidneys, uric acid as well as TGF-β and VEGF.
Material and methods We examined 30 ambulatory patients (9 Female and 21 Male), aged 18-50 years with nontreated essential hypertension (HT). The control group was of 16 healthy volunteers with age and gender matched (C).
Results In hypertension (HT) blood pressure was higher than control (C): systolic (148.88 ± 6.39 mm Hg vs. 115 ± ± 9.66 mm Hg), diastolic (95 ± 4.35 mm Hg vs. 68.44 ± ± 8.11 mm Hg), pulse pressure (53.83 ± 6.65 mm Hg vs. 46.56 ± 5.39 mm Hg). We did not reveal significant differences in serum concentration of TGF-β and VEGF between the examined and the control group. In HT the significant positive correlation between VEGF and pulse pressure (r = 0.41, p < 0.03) was observed. Only multifactorial correlation showed that LVMI was related to GFR and NAG excertion (r = 0.66, p < 0.003) but no correlation was found between uric acid and function of structure cardiovascular system in hypertensive patient.
Conclusions Our study suggested that both VEGF and TGF-β in the early period of arterial hypertension can take a part in development of cardiovascular system complications and kidney function.