Nitrendipine and nitroglicerine efficacy and safety in reducing unexpected high blood pressure in hypertensive outpatients

Jarosław Królczyk; Janusz Kąkol; Barbara Gryglewska; Elżbieta Siudmak-Bobela; Dorota Telesińska-Jasiówka; Kazimierz Janicki; Tomasz Grodzicki

Vol 13, No 4 (2009)

Original paper

Published online: 2009-07-21

View PDF (Polish)

Download PDF file

Get Citation

Nitrendipine and nitroglicerine efficacy and safety in reducing unexpected high blood pressure in hypertensive outpatients

Jarosław Królczyk, Janusz Kąkol, Barbara Gryglewska, Elżbieta Siudmak-Bobela, Dorota Telesińska-Jasiówka, Kazimierz Janicki, Tomasz Grodzicki

Nadciśnienie tętnicze 2009;13(4):239-245.

Vol 13, No 4 (2009)

Prace oryginalne

Published online: 2009-07-21

Abstract

Background The purpose of this work was to assess the hypotensive effect of nitrendipine (NTD), nitroglicerine (NTG) or combination of those two drugs in hypertensive patients with unexpected increase of blood pressure. This work evaluated hypotensive efficacy and safety of these drugs.
Material and methods Enrolled were adults admitted to Emergency Department with unexpected increase of systolic blood pressure (SBP) ranging 180-240 mm Hg and/or diastolic blood pressure (DBP) ranging 110-130 mm Hg. Urgent treatment of the hypertension with NTD, NTG or their combination were started. At the beginning measurement of the blood pressure and pulse rate were taken after 2 and 5 minutes and later after each 15 minutes in 3 hour observation period. In statistical analysis χ2 test, variation analysis with F Snedecor test and posthoc Duncan test were used.
Results Eighty three patients were enrolled in the study. The analysis confirmed that both drugs (NTG and NTD) and their combination caused relevant decrease in SBP and DBP. An increase in pulse rate at the beginning of the NTG treatment was observed. In combined treatment with NTG and NTD blood pressure decreased slowly and pulse rate did not increase. There was not serious side-effects during the observation.
Conclusions Treatment by NTG, NTD or combination of these drugs in urgent hypertensive cases was effective, save and well-tolerated. The weakest effect was after using NTG. Combined treatment with NTG and NTD was more advantageous with regard to hemodynamic effects what could be helpful in treatment of the coronary ischemic disease patients.