open access

Vol 13, No 4 (2009)
Prace oryginalne
Published online: 2009-07-21
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Nitrendipine and nitroglicerine efficacy and safety in reducing unexpected high blood pressure in hypertensive outpatients

Jarosław Królczyk, Janusz Kąkol, Barbara Gryglewska, Elżbieta Siudmak-Bobela, Dorota Telesińska-Jasiówka, Kazimierz Janicki, Tomasz Grodzicki
Nadciśnienie tętnicze 2009;13(4):239-245.

open access

Vol 13, No 4 (2009)
Prace oryginalne
Published online: 2009-07-21

Abstract

Background The purpose of this work was to assess the hypotensive effect of nitrendipine (NTD), nitroglicerine (NTG) or combination of those two drugs in hypertensive patients with unexpected increase of blood pressure. This work evaluated hypotensive efficacy and safety of these drugs.
Material and methods Enrolled were adults admitted to Emergency Department with unexpected increase of systolic blood pressure (SBP) ranging 180-240 mm Hg and/or diastolic blood pressure (DBP) ranging 110-130 mm Hg. Urgent treatment of the hypertension with NTD, NTG or their combination were started. At the beginning measurement of the blood pressure and pulse rate were taken after 2 and 5 minutes and later after each 15 minutes in 3 hour observation period. In statistical analysis χ2 test, variation analysis with F Snedecor test and posthoc Duncan test were used.
Results Eighty three patients were enrolled in the study. The analysis confirmed that both drugs (NTG and NTD) and their combination caused relevant decrease in SBP and DBP. An increase in pulse rate at the beginning of the NTG treatment was observed. In combined treatment with NTG and NTD blood pressure decreased slowly and pulse rate did not increase. There was not serious side-effects during the observation.
Conclusions Treatment by NTG, NTD or combination of these drugs in urgent hypertensive cases was effective, save and well-tolerated. The weakest effect was after using NTG. Combined treatment with NTG and NTD was more advantageous with regard to hemodynamic effects what could be helpful in treatment of the coronary ischemic disease patients.

Abstract

Background The purpose of this work was to assess the hypotensive effect of nitrendipine (NTD), nitroglicerine (NTG) or combination of those two drugs in hypertensive patients with unexpected increase of blood pressure. This work evaluated hypotensive efficacy and safety of these drugs.
Material and methods Enrolled were adults admitted to Emergency Department with unexpected increase of systolic blood pressure (SBP) ranging 180-240 mm Hg and/or diastolic blood pressure (DBP) ranging 110-130 mm Hg. Urgent treatment of the hypertension with NTD, NTG or their combination were started. At the beginning measurement of the blood pressure and pulse rate were taken after 2 and 5 minutes and later after each 15 minutes in 3 hour observation period. In statistical analysis χ2 test, variation analysis with F Snedecor test and posthoc Duncan test were used.
Results Eighty three patients were enrolled in the study. The analysis confirmed that both drugs (NTG and NTD) and their combination caused relevant decrease in SBP and DBP. An increase in pulse rate at the beginning of the NTG treatment was observed. In combined treatment with NTG and NTD blood pressure decreased slowly and pulse rate did not increase. There was not serious side-effects during the observation.
Conclusions Treatment by NTG, NTD or combination of these drugs in urgent hypertensive cases was effective, save and well-tolerated. The weakest effect was after using NTG. Combined treatment with NTG and NTD was more advantageous with regard to hemodynamic effects what could be helpful in treatment of the coronary ischemic disease patients.
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Keywords

urgency; treatment; nitrendipine; nitrogli

About this article
Title

Nitrendipine and nitroglicerine efficacy and safety in reducing unexpected high blood pressure in hypertensive outpatients

Journal

Arterial Hypertension

Issue

Vol 13, No 4 (2009)

Pages

239-245

Published online

2009-07-21

Bibliographic record

Nadciśnienie tętnicze 2009;13(4):239-245.

Keywords

urgency
treatment
nitrendipine
nitrogli

Authors

Jarosław Królczyk
Janusz Kąkol
Barbara Gryglewska
Elżbieta Siudmak-Bobela
Dorota Telesińska-Jasiówka
Kazimierz Janicki
Tomasz Grodzicki

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