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Fibrinolysis in hypertensive patients with glomerulonephritis
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Abstract
Background The role of fibrinolysis and serotonin in glomerulonephritis is still the matter of controversy. In essential hypertension fibrinolytic activity is diminished. The aim of the study was to assess some fibrinolytic parameters, in patients with glomerulonephritis in relation to healthy volunteers.
Material and methods Hypertensive patients with biopsyproven glomerulonephritis and normal renal function were treated for three months with nitrendipine (40 mg/day) (n = 18) or enalapril (20 mg/day) (n = 16). Healthy volunteers served as a control group. Activities of tPA and PAI-1 (amidolytic method), concentrations of tPA, PAI and tPA/PAI complexes (EIA) were studied by means of commercially available kits (Spectrolyse, Biopool, Sweden, Technoclone, Austria, respectively). Euglobulin clot lysis time (ECLT) was measured according to Kowarzyk and Buluk.
Results Diminished activity of tPA and a significant prolongation of ECLT was observed in hypertensive patients with glomerulonephritis when compared to healthy volunteers (p < 0.05). Concentration and activity of PAI were found to be higher in hypertensive patients when compared to the control group (p < 0.01). After 3 months of treatment with enalapril PAI concentration and activity decreased significantly, whereas in nitrendipine group a rise in tPA concentration was seen.
Conclusions Impairment in fibrinolysis in glomerulonephritis in hypertensive patients, may contribute to the increased risk of thromboembolic complications and accelerated atherosclerosis observed in these patients. Hypertensive treatment may favourably affect fibrinolysis in these patients.
Abstract
Background The role of fibrinolysis and serotonin in glomerulonephritis is still the matter of controversy. In essential hypertension fibrinolytic activity is diminished. The aim of the study was to assess some fibrinolytic parameters, in patients with glomerulonephritis in relation to healthy volunteers.
Material and methods Hypertensive patients with biopsyproven glomerulonephritis and normal renal function were treated for three months with nitrendipine (40 mg/day) (n = 18) or enalapril (20 mg/day) (n = 16). Healthy volunteers served as a control group. Activities of tPA and PAI-1 (amidolytic method), concentrations of tPA, PAI and tPA/PAI complexes (EIA) were studied by means of commercially available kits (Spectrolyse, Biopool, Sweden, Technoclone, Austria, respectively). Euglobulin clot lysis time (ECLT) was measured according to Kowarzyk and Buluk.
Results Diminished activity of tPA and a significant prolongation of ECLT was observed in hypertensive patients with glomerulonephritis when compared to healthy volunteers (p < 0.05). Concentration and activity of PAI were found to be higher in hypertensive patients when compared to the control group (p < 0.01). After 3 months of treatment with enalapril PAI concentration and activity decreased significantly, whereas in nitrendipine group a rise in tPA concentration was seen.
Conclusions Impairment in fibrinolysis in glomerulonephritis in hypertensive patients, may contribute to the increased risk of thromboembolic complications and accelerated atherosclerosis observed in these patients. Hypertensive treatment may favourably affect fibrinolysis in these patients.
Keywords
fibrinolytic system; hypotensive therapy; atherosclerosis
Title
Fibrinolysis in hypertensive patients with glomerulonephritis
Journal
Issue
Article type
Original paper
Pages
336-340
Published online
2009-12-04
Page views
653
Article views/downloads
1294
Bibliographic record
Nadciśnienie tętnicze 2009;13(5):336-340.
Keywords
fibrinolytic system
hypotensive therapy
atherosclerosis
Authors
Jolanta Małyszko
Jacek S. Małyszko
Michał Myśliwiec
Tetsumei Urano