open access

Vol 13, No 6 (2009)
Prace oryginalne
Published online: 2010-02-26
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Influence of endothelin on geometry of heart left ventricule in patients with essential hypertension

Mariusz Łapiński, Agnieszka Kuch-Wocial, Jacek Lewandowski, Bożenna Wocial, Zbigniew Gaciong
Nadciśnienie tętnicze 2009;13(6):397-409.

open access

Vol 13, No 6 (2009)
Prace oryginalne
Published online: 2010-02-26

Abstract

Background Left ventricular hypertrophy (LVH) stays main end-organ complication of arterial hypertension. In a course of untreated hypertension left ventricule geometry is changed. An influence of different hormones on LVH and left ventricular geometry is still unclear. In present study a potential influence of endothelin and catecholamines on LVH in hypertensive patients has been investigated.
Material and methods The study included 122 untreated subjects with mild-to-moderate hypertension (51F/71M) and 20 healthy controls, in mean age 45.5 ± 9 yrs and 41.6 ± 6 yrs respectively. Blood samples for endothelin and catecholamines were taken in recumbent position after 30 min of rest. Twenty-four hour ambulatory blood pressure monitoring was obtained using SpaceLabs 90207. Echocardiography was performed using Hewlett Packard AC 77020.
Results Higher plasma endothelin and noradrenalin concentrations and lower plasma adrenalin concentration were present in hypertensive patients with LVH than in those without LVH. Plasma endothelin concentration was similar in patients with normal left ventricle, eccentric and concentric hypertrophy. Patients with concentric remodeling had higher plasma endothelin and noradrenalin concentrations compare to patients with eccentric and concentric hypertrophy and lower adrenalin concentration compare to patients with eccentric hypertrophy.
Conclusion Presented results may suggest that endothelin influences LVH during its early stages of development.

Abstract

Background Left ventricular hypertrophy (LVH) stays main end-organ complication of arterial hypertension. In a course of untreated hypertension left ventricule geometry is changed. An influence of different hormones on LVH and left ventricular geometry is still unclear. In present study a potential influence of endothelin and catecholamines on LVH in hypertensive patients has been investigated.
Material and methods The study included 122 untreated subjects with mild-to-moderate hypertension (51F/71M) and 20 healthy controls, in mean age 45.5 ± 9 yrs and 41.6 ± 6 yrs respectively. Blood samples for endothelin and catecholamines were taken in recumbent position after 30 min of rest. Twenty-four hour ambulatory blood pressure monitoring was obtained using SpaceLabs 90207. Echocardiography was performed using Hewlett Packard AC 77020.
Results Higher plasma endothelin and noradrenalin concentrations and lower plasma adrenalin concentration were present in hypertensive patients with LVH than in those without LVH. Plasma endothelin concentration was similar in patients with normal left ventricle, eccentric and concentric hypertrophy. Patients with concentric remodeling had higher plasma endothelin and noradrenalin concentrations compare to patients with eccentric and concentric hypertrophy and lower adrenalin concentration compare to patients with eccentric hypertrophy.
Conclusion Presented results may suggest that endothelin influences LVH during its early stages of development.
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Keywords

hypertension; left ventricular hypertrophy; endothelin; catecholamines

About this article
Title

Influence of endothelin on geometry of heart left ventricule in patients with essential hypertension

Journal

Arterial Hypertension

Issue

Vol 13, No 6 (2009)

Pages

397-409

Published online

2010-02-26

Bibliographic record

Nadciśnienie tętnicze 2009;13(6):397-409.

Keywords

hypertension
left ventricular hypertrophy
endothelin
catecholamines

Authors

Mariusz Łapiński
Agnieszka Kuch-Wocial
Jacek Lewandowski
Bożenna Wocial
Zbigniew Gaciong

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