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Influence of endothelin on geometry of heart left ventricule in patients with essential hypertension
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Abstract
Material and methods The study included 122 untreated subjects with mild-to-moderate hypertension (51F/71M) and 20 healthy controls, in mean age 45.5 ± 9 yrs and 41.6 ± 6 yrs respectively. Blood samples for endothelin and catecholamines were taken in recumbent position after 30 min of rest. Twenty-four hour ambulatory blood pressure monitoring was obtained using SpaceLabs 90207. Echocardiography was performed using Hewlett Packard AC 77020.
Results Higher plasma endothelin and noradrenalin concentrations and lower plasma adrenalin concentration were present in hypertensive patients with LVH than in those without LVH. Plasma endothelin concentration was similar in patients with normal left ventricle, eccentric and concentric hypertrophy. Patients with concentric remodeling had higher plasma endothelin and noradrenalin concentrations compare to patients with eccentric and concentric hypertrophy and lower adrenalin concentration compare to patients with eccentric hypertrophy.
Conclusion Presented results may suggest that endothelin influences LVH during its early stages of development.
Abstract
Material and methods The study included 122 untreated subjects with mild-to-moderate hypertension (51F/71M) and 20 healthy controls, in mean age 45.5 ± 9 yrs and 41.6 ± 6 yrs respectively. Blood samples for endothelin and catecholamines were taken in recumbent position after 30 min of rest. Twenty-four hour ambulatory blood pressure monitoring was obtained using SpaceLabs 90207. Echocardiography was performed using Hewlett Packard AC 77020.
Results Higher plasma endothelin and noradrenalin concentrations and lower plasma adrenalin concentration were present in hypertensive patients with LVH than in those without LVH. Plasma endothelin concentration was similar in patients with normal left ventricle, eccentric and concentric hypertrophy. Patients with concentric remodeling had higher plasma endothelin and noradrenalin concentrations compare to patients with eccentric and concentric hypertrophy and lower adrenalin concentration compare to patients with eccentric hypertrophy.
Conclusion Presented results may suggest that endothelin influences LVH during its early stages of development.
Keywords
hypertension; left ventricular hypertrophy; endothelin; catecholamines
About this articleTitle
Influence of endothelin on geometry of heart left ventricule in patients with essential hypertension
Journal
Issue
Article type
Original paper
Pages
397-409
Published online
2010-02-26
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551
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1462
Bibliographic record
Nadciśnienie tętnicze 2009;13(6):397-409.
Keywords
hypertension
left ventricular hypertrophy
endothelin
catecholamines
Authors
Mariusz Łapiński
Agnieszka Kuch-Wocial
Jacek Lewandowski
Bożenna Wocial
Zbigniew Gaciong