Vol 13, No 6 (2009)
Original paper
Published online: 2010-02-26
The association between 3020INSC mutation in NOD2 gene and arterial stiffness in hypertensives
Nadciśnienie tętnicze 2009;13(6):371-375.
Abstract
Background The innate immune system elicits an inflammatory
process which is believed to be involved in the development
of vascular damage in hypertension.
The NOD2 gene (CARD15) is involved in the control of
the innate immune system. The aim of this study was to
assess the occurrence of the 3020insC mutation in the
NOD2 gene in relation to vascular damage in
hypertensives.
Materials and methods In 466 hypertensives, genotyping
for 3020insC mutation, cholesterol, serum creatinine, and
echocardiography were carried out. Systolic (SBP) and
diastolic (DBP) blood pressure and pulse pressure (PP)
were taken at 2-3 month intervals for one year and treated
according to ESC/ESH guidelines.
Results The 3020insC mutation was found in 7.08% of
hypertensives and was associated with earlier onset of hypertension
48.2 ± 12.1 v. 42.8 ± 10.9, p < 0.01 (age of
pts). After one year of treatment, patients with the mutation
had significantly higher SBP (138.48 ± 18.35 v.
131.74 ± 14.97, p < 0.04) and PP (57.27 ± 14.04 v. 52.70
± 12.96, p < 0.04) than patients without the mutation,
whereas the number of drugs was the same in both groups.
Conclusions The results suggest that the 3020insC mutation is associated with earlier onset of hypertension and increased arterial stiffness.
Conclusions The results suggest that the 3020insC mutation is associated with earlier onset of hypertension and increased arterial stiffness.
Keywords: arterial stiffnessinnate immunityNOD2 mutation