Vol 14, No 1 (2010)
Original paper
Published online: 2010-04-27
Evaluation of hypotensive effect of telmisartan and telmisartan with hydrochlorothiazide in ambulatory blood pressure monitoring
Nadciśnienie tętnicze 2010;14(1):74-82.
Abstract
Background Arterial hypertension is known, independent
risk factor of cardiovascular disease. Elevated values of
blood pressure (BP) increase cardiovascular mortality and
are related to higher risk of myocardial infarction, stroke
and kidney failure. It was observed that myocardial infarction
and stroke occur more often in the early morning
hours. That’s way BP should be controlled through out
the whole day and especially in the morning hours. The
aim of the study was to evaluate the twenty-four-hour efficacy
and safety of telmisartan and telmisartan with hydrochlorothiazide
(HCTZ) in treatment of arterial hypertension
in clinical practice, in ambulatory patients, and especially
to evaluate if combined therapy reveals additionally
benefits in control of BP in the morning hours.
Material and methods A total of 320 patients in age above 18 years, with untreated, primary hypertension of I or II degree were recruited to the study. Telmisartan in dose of 40 mg or 80 mg or telmisartan with HCTZ (telmisartan 80 mg/ /HCTZ 12.5 mg) were prescribed to the patients. The study group was observed for 8 weeks. Office BP measurements and ABPM were performed.
Results During the study significant decrease of BP in ABPM in the morning hours (mean SBP 22.21 ± 11.11 mm Hg, mean DBP 11.62 ± 10.06 mm Hg) and significant decrease of office SBP and DBP measurements were observed.
Conclusion Telmisartan administered in monotherapy and as well as in combined therapy was very well tolerated by the patients, through out the whole study.
Material and methods A total of 320 patients in age above 18 years, with untreated, primary hypertension of I or II degree were recruited to the study. Telmisartan in dose of 40 mg or 80 mg or telmisartan with HCTZ (telmisartan 80 mg/ /HCTZ 12.5 mg) were prescribed to the patients. The study group was observed for 8 weeks. Office BP measurements and ABPM were performed.
Results During the study significant decrease of BP in ABPM in the morning hours (mean SBP 22.21 ± 11.11 mm Hg, mean DBP 11.62 ± 10.06 mm Hg) and significant decrease of office SBP and DBP measurements were observed.
Conclusion Telmisartan administered in monotherapy and as well as in combined therapy was very well tolerated by the patients, through out the whole study.
Keywords: arterial hypertensionABPMtelmisartanhydrochlorothiazidecombined therapy