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Postprandial lipemia in hyperlipemic men with arterial hypertension
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Abstract
Materials and methods In 60 normolipemic, normotensive, and 36 hyperlipemic, hypertensive men, and 34 hyperlipemic, normotensive men fasting and postprandial (induced by standardized rich-fat meal included 100 g fat) lipids, apolipoproteins A and B and hsCRP were determined. The impact of 6- or 12-weekly therapy with simvastatin (20 mg/day) or fenofibrate (267 mg/day) on measured parameters was determined in hyperlipemic men. Serum lipids were determined using routine methods, apolipoproteins A and B by immunoturbidimetric, and hsCRP by immunonefelometric method. Results In hypercholesterolemic men, independently on arterial hypertension existence, meal-induced lipemia changes (∆TG) were greater (p < 0.001) than in normotonic and normolipemic men (in control group). However, in hypertriglyceridemic men coexistence of hyperlipemia with AH was associated with low, comparable to controls, postprandial lipemia. Hypolipemic therapy with statin or fibrate reduced fasting lipids and postprandial ∆TG.
Conclusion The coexistence of arterial hypertension with hypertriglyceridemia is associated with decreased postprandial lipemia. The most probable cause of this phenomenon is the beneficial hypotonic drugs effect, acting i.e. through peroxysome proliferator activator receptors (PPARs) stimulation.
Abstract
Materials and methods In 60 normolipemic, normotensive, and 36 hyperlipemic, hypertensive men, and 34 hyperlipemic, normotensive men fasting and postprandial (induced by standardized rich-fat meal included 100 g fat) lipids, apolipoproteins A and B and hsCRP were determined. The impact of 6- or 12-weekly therapy with simvastatin (20 mg/day) or fenofibrate (267 mg/day) on measured parameters was determined in hyperlipemic men. Serum lipids were determined using routine methods, apolipoproteins A and B by immunoturbidimetric, and hsCRP by immunonefelometric method. Results In hypercholesterolemic men, independently on arterial hypertension existence, meal-induced lipemia changes (∆TG) were greater (p < 0.001) than in normotonic and normolipemic men (in control group). However, in hypertriglyceridemic men coexistence of hyperlipemia with AH was associated with low, comparable to controls, postprandial lipemia. Hypolipemic therapy with statin or fibrate reduced fasting lipids and postprandial ∆TG.
Conclusion The coexistence of arterial hypertension with hypertriglyceridemia is associated with decreased postprandial lipemia. The most probable cause of this phenomenon is the beneficial hypotonic drugs effect, acting i.e. through peroxysome proliferator activator receptors (PPARs) stimulation.
Keywords
postprandial lipemia; hyperlipemia; arterial hypertension
Title
Postprandial lipemia in hyperlipemic men with arterial hypertension
Journal
Issue
Article type
Original paper
Pages
66-73
Published online
2010-04-27
Page views
2219
Article views/downloads
4037
Bibliographic record
Nadciśnienie tętnicze 2010;14(1):66-73.
Keywords
postprandial lipemia
hyperlipemia
arterial hypertension
Authors
Anna Skoczyńska
Bogusława Kreczyńska
Rafał Poręba
Anna Wojakowska
Barbara Turczyn