Postprandial lipemia in hyperlipemic men with arterial hypertension

Abstract

Background Mechanisms of differential postprandial lipemia in various diseases need explanation. The aim of this study was to evaluate standardized meal-induced lipemia in hyperlipemic men diagnosed with arterial hypertension (AH). The effect of hypolipemic therapy on the serum postprandial lipids and high-sensitive C-reactive protein (hsCRP) concentration was also analysed.
Materials and methods In 60 normolipemic, normotensive, and 36 hyperlipemic, hypertensive men, and 34 hyperlipemic, normotensive men fasting and postprandial (induced by standardized rich-fat meal included 100 g fat) lipids, apolipoproteins A and B and hsCRP were determined. The impact of 6- or 12-weekly therapy with simvastatin (20 mg/day) or fenofibrate (267 mg/day) on measured parameters was determined in hyperlipemic men. Serum lipids were determined using routine methods, apolipoproteins A and B by immunoturbidimetric, and hsCRP by immunonefelometric method. Results In hypercholesterolemic men, independently on arterial hypertension existence, meal-induced lipemia changes (∆TG) were greater (p < 0.001) than in normotonic and normolipemic men (in control group). However, in hypertriglyceridemic men coexistence of hyperlipemia with AH was associated with low, comparable to controls, postprandial lipemia. Hypolipemic therapy with statin or fibrate reduced fasting lipids and postprandial ∆TG.
Conclusion The coexistence of arterial hypertension with hypertriglyceridemia is associated with decreased postprandial lipemia. The most probable cause of this phenomenon is the beneficial hypotonic drugs effect, acting i.e. through peroxysome proliferator activator receptors (PPARs) stimulation.