open access

Vol 14, No 1 (2010)
Prace oryginalne
Published online: 2010-04-27
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Evaluation of resistin in obese patients with hypertension

Katarzyna Musialik, Paweł Bogdański, Monika Szulińska
Nadciśnienie tętnicze 2010;14(1):48-54.

open access

Vol 14, No 1 (2010)
Prace oryginalne
Published online: 2010-04-27

Abstract

Background Resistin is an adipocytokine investigated as a possible etiologic link between excessive adiposity, insulin resistance and hypertension. The aim of the study was to evaluate of resistin concentration in obese hypertensive patients and to assess its relation to blood pressure.
Material and methods 25 obese hypertensive patients and 20 obese patients without hypertension were studied. Clinical examination and 24-hour blood pressure monitoring (ABPM) was done in all participants. On a base of ABPM results they were divided into two subgroups: non-dippers (14 patients) and dippers (11 patients). Concentrations of resistin were assessed with use of immunoenzymatic method (DRG Diagnostic).
Results
1. Plasma resistin levels in hypertensive patients with obesity significantly exceeded those observed in the group without hypertension (p < 0.01).
2. Significantly higher resistin concentrations were found in non-dipper hypertensives as compared to dipper hypertensives (p < 0.05).
3. Positive correlation between resistin levels and systolic blood pressure was found (r = 0.45; p < 0.05).
Conclusions
1. Resistin should be considered as potential factor in the complex pathogenesis of obesity related-hypertension.
2. The higher blood resistin levels in non-dipper hypertensives may indicate a possible influence of this adipocytokin on blood pressure profile.

Abstract

Background Resistin is an adipocytokine investigated as a possible etiologic link between excessive adiposity, insulin resistance and hypertension. The aim of the study was to evaluate of resistin concentration in obese hypertensive patients and to assess its relation to blood pressure.
Material and methods 25 obese hypertensive patients and 20 obese patients without hypertension were studied. Clinical examination and 24-hour blood pressure monitoring (ABPM) was done in all participants. On a base of ABPM results they were divided into two subgroups: non-dippers (14 patients) and dippers (11 patients). Concentrations of resistin were assessed with use of immunoenzymatic method (DRG Diagnostic).
Results
1. Plasma resistin levels in hypertensive patients with obesity significantly exceeded those observed in the group without hypertension (p < 0.01).
2. Significantly higher resistin concentrations were found in non-dipper hypertensives as compared to dipper hypertensives (p < 0.05).
3. Positive correlation between resistin levels and systolic blood pressure was found (r = 0.45; p < 0.05).
Conclusions
1. Resistin should be considered as potential factor in the complex pathogenesis of obesity related-hypertension.
2. The higher blood resistin levels in non-dipper hypertensives may indicate a possible influence of this adipocytokin on blood pressure profile.
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Keywords

arterial hypertension; obesity; resistin

About this article
Title

Evaluation of resistin in obese patients with hypertension

Journal

Arterial Hypertension

Issue

Vol 14, No 1 (2010)

Pages

48-54

Published online

2010-04-27

Bibliographic record

Nadciśnienie tętnicze 2010;14(1):48-54.

Keywords

arterial hypertension
obesity
resistin

Authors

Katarzyna Musialik
Paweł Bogdański
Monika Szulińska

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