open access
Evaluation of resistin in obese patients with hypertension
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Abstract
Material and methods 25 obese hypertensive patients and 20 obese patients without hypertension were studied. Clinical examination and 24-hour blood pressure monitoring (ABPM) was done in all participants. On a base of ABPM results they were divided into two subgroups: non-dippers (14 patients) and dippers (11 patients). Concentrations of resistin were assessed with use of immunoenzymatic method (DRG Diagnostic).
Results
1. Plasma resistin levels in hypertensive patients with obesity significantly exceeded those observed in the group without hypertension (p < 0.01).
2. Significantly higher resistin concentrations were found in non-dipper hypertensives as compared to dipper hypertensives (p < 0.05).
3. Positive correlation between resistin levels and systolic blood pressure was found (r = 0.45; p < 0.05).
Conclusions
1. Resistin should be considered as potential factor in the complex pathogenesis of obesity related-hypertension.
2. The higher blood resistin levels in non-dipper hypertensives may indicate a possible influence of this adipocytokin on blood pressure profile.
Abstract
Material and methods 25 obese hypertensive patients and 20 obese patients without hypertension were studied. Clinical examination and 24-hour blood pressure monitoring (ABPM) was done in all participants. On a base of ABPM results they were divided into two subgroups: non-dippers (14 patients) and dippers (11 patients). Concentrations of resistin were assessed with use of immunoenzymatic method (DRG Diagnostic).
Results
1. Plasma resistin levels in hypertensive patients with obesity significantly exceeded those observed in the group without hypertension (p < 0.01).
2. Significantly higher resistin concentrations were found in non-dipper hypertensives as compared to dipper hypertensives (p < 0.05).
3. Positive correlation between resistin levels and systolic blood pressure was found (r = 0.45; p < 0.05).
Conclusions
1. Resistin should be considered as potential factor in the complex pathogenesis of obesity related-hypertension.
2. The higher blood resistin levels in non-dipper hypertensives may indicate a possible influence of this adipocytokin on blood pressure profile.
Keywords
arterial hypertension; obesity; resistin
Title
Evaluation of resistin in obese patients with hypertension
Journal
Issue
Article type
Original paper
Pages
48-54
Published online
2010-04-27
Page views
625
Article views/downloads
1273
Bibliographic record
Nadciśnienie tętnicze 2010;14(1):48-54.
Keywords
arterial hypertension
obesity
resistin
Authors
Katarzyna Musialik
Paweł Bogdański
Monika Szulińska