Vol 14, No 2 (2010)
Review paper
Published online: 2010-05-19
Hypertensive patient under statin treatment - one goal achieved only?
Katarzyna Starzyk, Beata Wożakowska-Kapłon
Nadciśnienie tętnicze 2010;14(2):157-165.
Vol 14, No 2 (2010)
REVIEV
Published online: 2010-05-19
Abstract
Hypertension and hyperlipidemia are very common phenomenons
in adults, and they contribute to increasing risk
of cardiovascular diseases. Although statins are widely used
for cholesterol-lowering treatment, growing attention focuses
on other their pleiotropic actions.
It appears from the experimental studies, that they have
additional hypotensive effect in many patophysiological
mechanisms including impact on renin-angiotensin system,
vascular endothelium, sympathetic activity. Some
studies have also shown that statins have significant impact
on pressure reduction measured in the carotid artery
and decreasing wave reflection from the body. There is
convincing evidence that lipid-lowering treatment prevents
cardiovascular events in primary prevention subjects at very
high risk. It turned out in the available current studies
(JUPITER eg.), that it might be useful to start statins treatment
not only in high risk subjects but in moderate risk
ones, also. Although it requires future research. According
to results of randomized trials, the role of escalling doses of
statins to decrease cardiovascular risk and regres atherosclerosis
should be underlined. Some clinical evidence supports
that among other pleiotropic actions, they also modestly
lower blood pressure, especially in hypertensive patients,
regardless from cholesterol level.
Arterial Hypertension 2010, vol. 14, no 2, pages 157-165.
Abstract
Hypertension and hyperlipidemia are very common phenomenons
in adults, and they contribute to increasing risk
of cardiovascular diseases. Although statins are widely used
for cholesterol-lowering treatment, growing attention focuses
on other their pleiotropic actions.
It appears from the experimental studies, that they have
additional hypotensive effect in many patophysiological
mechanisms including impact on renin-angiotensin system,
vascular endothelium, sympathetic activity. Some
studies have also shown that statins have significant impact
on pressure reduction measured in the carotid artery
and decreasing wave reflection from the body. There is
convincing evidence that lipid-lowering treatment prevents
cardiovascular events in primary prevention subjects at very
high risk. It turned out in the available current studies
(JUPITER eg.), that it might be useful to start statins treatment
not only in high risk subjects but in moderate risk
ones, also. Although it requires future research. According
to results of randomized trials, the role of escalling doses of
statins to decrease cardiovascular risk and regres atherosclerosis
should be underlined. Some clinical evidence supports
that among other pleiotropic actions, they also modestly
lower blood pressure, especially in hypertensive patients,
regardless from cholesterol level.
Arterial Hypertension 2010, vol. 14, no 2, pages 157-165.
Keywords
statins; hypertension; cardivascular risk
Title
Hypertensive patient under statin treatment - one goal achieved only?
Journal
Arterial Hypertension
Issue
Vol 14, No 2 (2010)
Article type
Review paper
Pages
157-165
Published online
2010-05-19
Page views
1159
Article views/downloads
3649
Bibliographic record
Nadciśnienie tętnicze 2010;14(2):157-165.
Keywords
statins
hypertension
cardivascular risk
Authors
Katarzyna Starzyk
Beata Wożakowska-Kapłon
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