Izabela Klorek, Lucyna Woźnicka-Leśkiewicz, Anna Posadzy-Małaczyńska, Beata Begier-Krasińska, Paweł Gut, Maria Gryczyńska, Jerzy Sowiński, Maciej Frankiewicz
Nadciśnienie tętnicze 2010;14(3):227-234.
Vol 14, No 3 (2010)
REVIEV
Published online: 2010-08-05
Abstract
Background Carcinoids are neuroendocrine tumors which
develop in many different parts of gastrointestinal tract
and lungs. They occur with the frequency of 1-3/ 100 000
Their common feature is the ability to production and secretion
of hormone-like peptides and neurotransmitters.
The carcinoid syndrome is caused by dissemination of serotonin
producing neuroendocrine tumor. Symptoms of
carcinoid, such as: skin redness on the face and neck -
flash, tachycardia, vertiges, hyperhidrose and bronchospasm
are paroxysmal (periodic). Blood pressure elevation
is not a patognomic sign of carcinoid, but if it is, one should
be classified as secondary cause of arterial hypertension.
The measurement of: serotonin, it’s metabolite in the
urine-5-hydroxyindoloacetic acid, chromogranin A levels
and computed tomography, nuclear magnetic resonance,
ultrasonography, somatostatin receptor scintigraphy (SRS)
are crucial in the diagnostic process of carcinoid and in
localization of metastases.
Material and methods Sixty four-years old man was admitted
to the hospital because of cough attacks with slight
production of sputum which contained small amount of
blood, diarrhea, abdominal pain, paroxysmal redness of
the face and high blood pressure. Another patient, 69-years
old woman was hospitalized because of dyspnea, fatigue
and high blood pressure. Results The first patient’s bronchoscopy revealed lesion
confirming the diagnosis of carcinoid which was removed
from division of the left bronchus. In case of the second
patient with heart failure, tricuspid valve pathology and
redness of the face, SRS was performed. It revealed focal
increase in radio-accumulation in the patient’s body, what
was the reason of starting the therapy with long-acting
release somatostatin. The echosonography revealed advanced
complex tricuspid valve defect.
Conclusions In these two cases the carcinoid syndrome
was diagnosed. During the both patients’observation, the
blood pressure was normalized, but the regression of the
carcinoid syndrome process wasn’t achieved.
Arterial Hypertension 2010, vol. 14, no 3, pages 227-234
Abstract
Background Carcinoids are neuroendocrine tumors which
develop in many different parts of gastrointestinal tract
and lungs. They occur with the frequency of 1-3/ 100 000
Their common feature is the ability to production and secretion
of hormone-like peptides and neurotransmitters.
The carcinoid syndrome is caused by dissemination of serotonin
producing neuroendocrine tumor. Symptoms of
carcinoid, such as: skin redness on the face and neck -
flash, tachycardia, vertiges, hyperhidrose and bronchospasm
are paroxysmal (periodic). Blood pressure elevation
is not a patognomic sign of carcinoid, but if it is, one should
be classified as secondary cause of arterial hypertension.
The measurement of: serotonin, it’s metabolite in the
urine-5-hydroxyindoloacetic acid, chromogranin A levels
and computed tomography, nuclear magnetic resonance,
ultrasonography, somatostatin receptor scintigraphy (SRS)
are crucial in the diagnostic process of carcinoid and in
localization of metastases.
Material and methods Sixty four-years old man was admitted
to the hospital because of cough attacks with slight
production of sputum which contained small amount of
blood, diarrhea, abdominal pain, paroxysmal redness of
the face and high blood pressure. Another patient, 69-years
old woman was hospitalized because of dyspnea, fatigue
and high blood pressure. Results The first patient’s bronchoscopy revealed lesion
confirming the diagnosis of carcinoid which was removed
from division of the left bronchus. In case of the second
patient with heart failure, tricuspid valve pathology and
redness of the face, SRS was performed. It revealed focal
increase in radio-accumulation in the patient’s body, what
was the reason of starting the therapy with long-acting
release somatostatin. The echosonography revealed advanced
complex tricuspid valve defect.
Conclusions In these two cases the carcinoid syndrome
was diagnosed. During the both patients’observation, the
blood pressure was normalized, but the regression of the
carcinoid syndrome process wasn’t achieved.
Arterial Hypertension 2010, vol. 14, no 3, pages 227-234
Keywords
carcinoid; carcinoid syndrome; arterial hypertension
Title
Faces of the carcinoid syndrome in patients with hypertension
Journal
Arterial Hypertension
Issue
Vol 14, No 3 (2010)
Article type
Review paper
Pages
227-234
Published online
2010-08-05
Page views
2168
Article views/downloads
19219
Bibliographic record
Nadciśnienie tętnicze 2010;14(3):227-234.
Keywords
carcinoid
carcinoid syndrome
arterial hypertension
Authors
Izabela Klorek
Lucyna Woźnicka-Leśkiewicz
Anna Posadzy-Małaczyńska
Beata Begier-Krasińska
Paweł Gut
Maria Gryczyńska
Jerzy Sowiński
Maciej Frankiewicz