New potential targets of pharmacological attack in patients with hypertension

Franciszek Kokot; Lidia Hyla-Klekot

Vol 14, No 3 (2010)

Editorial

Published online: 2010-08-05

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New potential targets of pharmacological attack in patients with hypertension

Franciszek Kokot, Lidia Hyla-Klekot

Nadciśnienie tętnicze 2010;14(3):171-176.

Vol 14, No 3 (2010)

Artykuły redakcyjne

Published online: 2010-08-05

Abstract

There is no doubt, that the cause of arterial hypertension is multifactorial. The main determinants of blood pressure are volemia and blood vessel resistance. These two determinants are the target of all available antihypertensive drugs (diuretics, sympathicolytics, Ca-blockers, blockers of the RAA cascade). Identification of new pathogenetic factors of arterial hypertension initiated studies of new drugs targeting: WNK kinases, „lipid rafts” and caveolae of plasma membranes, Na+, K+, 2Cl co-transporter 1 and two (NKCC1 and NKCC2), receptor and nonreceptor tyrosine kinases, circulating microparticles, endocrine function of the adipose tissue, extracellular matrix of blood vessels, lymphocytes.
In the near future we may expect data reporting on the suitability of new antihypertensive drugs targeting the above mentioned pathogenetic factors T.
Arterial Hypertension 2010, vol. 14, no 3, pages 171-176