Vol 14, No 3 (2010)
Editorial
Published online: 2010-08-05
New potential targets of pharmacological attack in patients with hypertension
Nadciśnienie tętnicze 2010;14(3):171-176.
Abstract
There is no doubt, that the cause of arterial hypertension is
multifactorial. The main determinants of blood pressure
are volemia and blood vessel resistance. These two determinants
are the target of all available antihypertensive
drugs (diuretics, sympathicolytics, Ca-blockers, blockers of
the RAA cascade). Identification of new pathogenetic factors
of arterial hypertension initiated studies of new drugs
targeting: WNK kinases, „lipid rafts” and caveolae of
plasma membranes, Na+, K+, 2Cl co-transporter 1 and
two (NKCC1 and NKCC2), receptor and nonreceptor tyrosine
kinases, circulating microparticles, endocrine function
of the adipose tissue, extracellular matrix of blood vessels,
lymphocytes.
In the near future we may expect data reporting on the suitability of new antihypertensive drugs targeting the above mentioned pathogenetic factors T.
Arterial Hypertension 2010, vol. 14, no 3, pages 171-176
In the near future we may expect data reporting on the suitability of new antihypertensive drugs targeting the above mentioned pathogenetic factors T.
Arterial Hypertension 2010, vol. 14, no 3, pages 171-176
Keywords: arterial hypertensionpathophysiologytherapy