open access

Vol 28, No 4 (2022)
Research paper
Published online: 2022-12-30
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Leukotrienes in the atherosclerotic cardiovascular diseases — a systematic review

Agnieszka Wachsmann-Maga1, Marek Kaszuba2, Mikołaj Maga23, Aleksandra Włodarczyk4, Jakub Krężel3, Paweł Kaczmarczyk13, Katarzyna Bogucka3, Paweł Maga13
DOI: 10.5603/AA.2022.0013
·
Acta Angiologica 2022;28(4):147-153.
Affiliations
  1. Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland, Krakow, Poland
  2. Departament of Rehabilitation in Internal Medicine, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
  3. Clinical Department of Angiology, University Hospital in Krakow, Krakow, Poland
  4. Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland

open access

Vol 28, No 4 (2022)
Original papers
Published online: 2022-12-30

Abstract

Introduction: The role of inflammation in the pathogenesis of atherosclerotic diseases is strongly suggested.
There are multiple studies indicating the possibility of a pathophysiological connection between atherosclerotic
changes and leukotrienes (LTs) — the products of arachidonic acid metabolism. The goal of this systematic
review, performed in line with the PRISMA statement, was to investigate the potential role of LTs in the pathophysiology
of atherosclerotic cardiovascular diseases (CVD).

Material and methods: The MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews were
searched to identify the potentially eligible studies. Publications that contained information on any type of LTs
identified in blood or urine were included in the review. A database search identified 2082 records. Reliable LTs
identification in patients with CVD was used in 30 publications.

Results: Stable and acute forms of coronary artery disease are characterized by the overproduction of different
types of LTs. The level of LTB4 and LTC4 in the blood is elevated in patients with cerebral ischemia. Patients with
acute and chronic peripheral artery disease have elevated levels of LTE4 in urine.

Conclusions: The findings of this systematic review show that there is a clear tendency to indicate the association
of cardiovascular atherosclerotic diseases with increased production of LTs. This dependency detailed
characteristic remains unclear and the question on the impact of elevated leukotrienes on clinical atherosclerotic
disease manifestations is still open.

Abstract

Introduction: The role of inflammation in the pathogenesis of atherosclerotic diseases is strongly suggested.
There are multiple studies indicating the possibility of a pathophysiological connection between atherosclerotic
changes and leukotrienes (LTs) — the products of arachidonic acid metabolism. The goal of this systematic
review, performed in line with the PRISMA statement, was to investigate the potential role of LTs in the pathophysiology
of atherosclerotic cardiovascular diseases (CVD).

Material and methods: The MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews were
searched to identify the potentially eligible studies. Publications that contained information on any type of LTs
identified in blood or urine were included in the review. A database search identified 2082 records. Reliable LTs
identification in patients with CVD was used in 30 publications.

Results: Stable and acute forms of coronary artery disease are characterized by the overproduction of different
types of LTs. The level of LTB4 and LTC4 in the blood is elevated in patients with cerebral ischemia. Patients with
acute and chronic peripheral artery disease have elevated levels of LTE4 in urine.

Conclusions: The findings of this systematic review show that there is a clear tendency to indicate the association
of cardiovascular atherosclerotic diseases with increased production of LTs. This dependency detailed
characteristic remains unclear and the question on the impact of elevated leukotrienes on clinical atherosclerotic
disease manifestations is still open.

Get Citation

Keywords

atherosclerosis; coronary artery disease; leukotrienes; review

Supp./Additional Files (3)
Supplementary Table 1. An electronic search of the MEDLINE, EMBASE and Cochrane Database of Systematic Reviews – publication to 10 August 2020
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Supplemetary Figure 1. Risk of bias graph: a review of authors’ judgments regarding each risk of bias question presented as percentages across all studies included in the final review.
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448KB
Supplemetary Table 2. Characteristics of the analyzed studies.
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61KB
About this article
Title

Leukotrienes in the atherosclerotic cardiovascular diseases — a systematic review

Journal

Acta Angiologica

Issue

Vol 28, No 4 (2022)

Article type

Research paper

Pages

147-153

Published online

2022-12-30

Page views

516

Article views/downloads

81

DOI

10.5603/AA.2022.0013

Bibliographic record

Acta Angiologica 2022;28(4):147-153.

Keywords

atherosclerosis
coronary artery disease
leukotrienes
review

Authors

Agnieszka Wachsmann-Maga
Marek Kaszuba
Mikołaj Maga
Aleksandra Włodarczyk
Jakub Krężel
Paweł Kaczmarczyk
Katarzyna Bogucka
Paweł Maga

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