dostęp otwarty
Expression of genes ESR1 and ESR2 encoding estrogen receptors and cognitive functioning in patients with depression
, 1, 1, 2, 1
Afiliacje- Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
- Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland
dostęp otwarty
Streszczenie
Introduction: Researchers are increasingly interested in the role of sex hormones and their impact on other than reproductive systems, including mental functioning. Estrogens acting through the receptors ESR1 and ESR2 may participate in the regulation of mood and cognitive functions. The aim of the study was to evaluate the expression of genes ESR1 and ESR2 encoding estrogen receptors in depressive disorders and search for relationship between gene expression, cognitive functioning and socio-demographic data. Material and methods: A total of 236 people (131 depressed patients, 105 healthy controls) participated in the study. Socio-demographic data were collected. Neuropsychological test have been carried out to evaluatecognitive functions. Venous blood was collected from all participants. RT-PCR was performed to evaluate the expression of genes ESR1 and ESR2 at mRNA level and enzyme-linked immunosorbent assay (ELISA) test to evaluate gene expression at protein level. Results: Participants suffering from depression were characterized by a higher level of ESR1 expression both at the mRNA and protein level. Expression of ESR1 and ESR2 genes might be related to functioning in the examined cognitive areas. Expression of ESR1 and ESR2 genes does not differ statistically significantly in terms of gender. Conclusions: ESR1 and ESR2 genes might play an important role in depression and cognitive functioning.
Streszczenie
Introduction: Researchers are increasingly interested in the role of sex hormones and their impact on other than reproductive systems, including mental functioning. Estrogens acting through the receptors ESR1 and ESR2 may participate in the regulation of mood and cognitive functions. The aim of the study was to evaluate the expression of genes ESR1 and ESR2 encoding estrogen receptors in depressive disorders and search for relationship between gene expression, cognitive functioning and socio-demographic data. Material and methods: A total of 236 people (131 depressed patients, 105 healthy controls) participated in the study. Socio-demographic data were collected. Neuropsychological test have been carried out to evaluatecognitive functions. Venous blood was collected from all participants. RT-PCR was performed to evaluate the expression of genes ESR1 and ESR2 at mRNA level and enzyme-linked immunosorbent assay (ELISA) test to evaluate gene expression at protein level. Results: Participants suffering from depression were characterized by a higher level of ESR1 expression both at the mRNA and protein level. Expression of ESR1 and ESR2 genes might be related to functioning in the examined cognitive areas. Expression of ESR1 and ESR2 genes does not differ statistically significantly in terms of gender. Conclusions: ESR1 and ESR2 genes might play an important role in depression and cognitive functioning.
Słowa kluczowe
depression; estrogen receptor; cognitive functions; ESR1; ESR2
Informacje o artykuleTytuł
Expression of genes ESR1 and ESR2 encoding estrogen receptors and cognitive functioning in patients with depression
Czasopismo
Journal of Sexual and Mental Health
Numer
Tom 21 (2023): Continuous Publishing
Typ artykułu
Praca badawcza (oryginalna)
Strony
12-20
Opublikowany online
2023-09-14
Wyświetlenia strony
467
Wyświetlenia/pobrania artykułu
200
DOI
Rekord bibliograficzny
Journal of Sexual and Mental Health 2023;21:12-20.
Słowa kluczowe
depression
estrogen receptor
cognitive functions
ESR1
ESR2
Autorzy
Maria Kozłowiec
Małgorzata Gałecka
Agata Orzechowska
Janusz Szemraj
Piotr Gałecki
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