Vol 27, No 1 (2022)
Review paper
Published online: 2021-11-05

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Doses, fractionations, constraints for stereotactic radiotherapy

Simona Borghesi1, Cynthia Aristei2, Francesco Marampon3
Rep Pract Oncol Radiother 2022;27(1):10-14.


This paper describes how to select the most appropriate stereotactic radiotherapy (SRT) dose and fractionation scheme according to lesion size and site, organs at risk (OARs) proximity and the biological effective dose. In single-dose SRT, 15–34 Gy are generally used while in fractionated SRT 30 and 75 Gy in 2–5 fractions are administered.

The ICRU Report No. 91, which is specifically dedicated to SRT treatments, provided indications for dose prescription (with its definition and essential steps), dose delivery and optimal coverage which was defined as the best planning target volume coverage that can be obtained in the irradiated district. Calculation algorithms and OAR dose constraints are provided as well as treatment planning system characteristics, suggested beam energy and multileaf collimator leaf size. Finally, parameters for irradiation geometry and plan quality are also reported.


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