open access
Cognitive performance of medulloblastoma tumour survivors related to the area of cerebellum damage
Affiliations- Institute of Psychology, Pedagogical University in Kraków, Krakow, Poland
- Division of Diagnostic Imaging Department of Radiology and Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia Katowice, Katowice, Poland
- Diplomstudium Humanmedizin, Medizinische Universität Wien, Wien, Austria
- Department of Paediatric Oncology, Haematology and Chemotherapy, Medical University of Silesia, Katowice, Poland
open access
Abstract
Background: The aim of the study was to determine the relationship between a damaged cerebellum area and the cognitive performance of medulloblastoma tumour survivors. Also, age-based differences in cognitive performance were tested.
Materials and methods: Magnetic resonance imaging (MRI) technique was used to obtain brain images of survivors. The cognitive performance was tested using Wechsler Intelligence Scale for Children Revised (WISC-R) and Wechsler Adult Intelligence Scale (WAIS). Statistical analysis was performed with highly robust permutation tests.
Results: There were two anatomical features strongly influencing the cognitive performance of survivors. The extension of the foramen of Luschka had a negative impact on the overall verbal IQ score and some non-verbal scales while the excision of the middle part of the vermis influenced scores in such scales as arithmetic and picture completing.
Conclusions: Children with postoperative damages in the area of the middle part of the vermis are more likely to suffer from cognitive dysfunctions after the end of the treatment.
Abstract
Background: The aim of the study was to determine the relationship between a damaged cerebellum area and the cognitive performance of medulloblastoma tumour survivors. Also, age-based differences in cognitive performance were tested.
Materials and methods: Magnetic resonance imaging (MRI) technique was used to obtain brain images of survivors. The cognitive performance was tested using Wechsler Intelligence Scale for Children Revised (WISC-R) and Wechsler Adult Intelligence Scale (WAIS). Statistical analysis was performed with highly robust permutation tests.
Results: There were two anatomical features strongly influencing the cognitive performance of survivors. The extension of the foramen of Luschka had a negative impact on the overall verbal IQ score and some non-verbal scales while the excision of the middle part of the vermis influenced scores in such scales as arithmetic and picture completing.
Conclusions: Children with postoperative damages in the area of the middle part of the vermis are more likely to suffer from cognitive dysfunctions after the end of the treatment.
Keywords
medulloblastoma; cognitive performance; cerebellum; MRI
Supp./Additional Files (1)
About this articleTitle
Cognitive performance of medulloblastoma tumour survivors related to the area of cerebellum damage
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Article type
Research paper
Pages
1037-1044
Published online
2022-10-03
Page views
3038
Article views/downloads
262
DOI
Bibliographic record
Rep Pract Oncol Radiother 2022;27(6):1037-1044.
Keywords
medulloblastoma
cognitive performance
cerebellum
MRI
Authors
Natalia Maja Józefacka
Magdalena Dagmara Machnikowska-Sokołowska
Mateusz Franciszek Kołek
Katarzyna Jadwiga Gruszczyńska
Katarzyna Musioł
References (30)- Oeffinger KC, Mertens AC, Sklar CA, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006; 355(15): 1572–1582.
- Cheung LLT, Wakefield CE, Ellis SJ, et al. Neuropsychology reports for childhood brain tumor survivors: implementation of recommendations at home and school. Pediatr Blood Cancer. 2014; 61(6): 1080–1087.
- Heideman R, Havens J. Brain tumors. In: Mirro J. ed. Childhood cancer: A handbook from St. Jude children’s research hospital. Perseus, Cambridge, MA 2000: 363–382.
- Conklin HM, Ashford JM, Di Pinto M, et al. Computerized assessment of cognitive late effects among adolescent brain tumor survivors. J Neurooncol. 2013; 113(2): 333–340.
- Moore BD. Neurocognitive outcomes in survivors of childhood cancer. J Pediatr Psychol. 2005; 30(1): 51–63.
- Mulhern RK, Kepner JL, Thomas PR, et al. Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study. J Clin Oncol. 1998; 16(5): 1723–1728.
- Dennis M, Hetherington C, Spiegler B. Memory and attention after childhood brain tumors. Medical and Pediatric Oncology. 1998; 30(S1): 25–33, doi: 10.1002/(sici)1096-911x(1998)30:1+<25::aid-mpo4>3.0.co;2-a.
- Reeves CB, Palmer SL, Reddick WE, et al. Attention and memory functioning among pediatric patients with medulloblastoma. J Pediatr Psychol. 2006; 31(3): 272–280.
- Mulhern R, Merchant T, Gajjar A, et al. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol. 2004; 5(7): 399–408.
- Palmer SL, Armstrong C, Onar-Thomas A, et al. Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol. 2013; 31(28): 3494–3500.
- Reddick WE, Glass JO, Palmer SL, et al. Atypical white matter volume development in children following craniospinal irradiation. Neuro Oncol. 2005; 7(1): 12–19.
- Spiegler BJ, Bouffet E, Greenberg ML, et al. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol. 2004; 22(4): 706–713.
- Ris MD, Packer R, Goldwein J, et al. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J Clin Oncol. 2001; 19(15): 3470–3476.
- Hoppe-Hirsch E, Renier D, Lellouch-Tubiana A, et al. Medulloblastoma in childhood: progressive intellectual deterioration. Childs Nerv Syst. 1990; 6(2): 60–65.
- Robinson KE, Fraley CE, Pearson MM, et al. Neurocognitive late effects of pediatric brain tumors of the posterior fossa: a quantitative review. J Int Neuropsychol Soc. 2013; 19(1): 44–53.
- Stavinoha PL, Askins MA, Powell SK, et al. Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Bioengineering (Basel). 2018; 5(3).
- Tonning Olsson I, Perrin S, Lundgren J, et al. Long-term cognitive sequelae after pediatric brain tumor related to medical risk factors, age, and sex. Pediatr Neurol. 2014; 51(4): 515–521.
- Catsman-Berrevoets CE, Aarsen FK. The spectrum of neurobehavioural deficits in the Posterior Fossa Syndrome in children after cerebellar tumour surgery. Cortex. 2010; 46(7): 933–946.
- Avula S, Spiteri M, Kumar R, et al. Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. Quant Imaging Med Surg. 2016; 6(5): 535–544.
- R Core Team (2013). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org/.
- Wickham H, Bryan J (2019). readxl: Read Excel Files. R package version 1.3.1. https://CRAN.R-project.org/package=readxl.
- Hothorn T, Hornik K, Wiel Mv, et al. A Lego System for Conditional Inference. Amer Statist. 2006; 60(3): 257–263.
- Moral PD, Doucet A, Jasra A. On adaptive resampling strategies for sequential Monte Carlo methods. Bernoulli. 2012; 18(1).
- Cohen, J. (2013). Statistical power analysis for the behavioral sciences. Academic press. 2013.
- Ryan JJ, Gontkovsky ST, Kreiner DS, et al. Wechsler Adult Intelligence Scale-Fourth Edition performance in relapsing-remitting multiple sclerosis. J Clin Exp Neuropsychol. 2012; 34(6): 571–579.
- Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008; 108(1): 18–30.
- Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014; 111(8): 119–125.
- Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol. 2010; 14(2): 106–115.
- Riva D, Giorgi C. The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours. Brain. 2000; 123 ( Pt 5): 1051–1061.
- Puget S, Boddaert N, Viguier D, et al. Injuries to inferior vermis and dentate nuclei predict poor neurological and neuropsychological outcome in children with malignant posterior fossa tumors. Cancer. 2009; 115(6): 1338–1347.