open access

Vol 27, No 6 (2022)
Research paper
Published online: 2022-10-03
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Cognitive performance of medulloblastoma tumour survivors related to the area of cerebellum damage

Natalia Maja Józefacka1, Magdalena Dagmara Machnikowska-Sokołowska2, Mateusz Franciszek Kołek3, Katarzyna Jadwiga Gruszczyńska2, Katarzyna Musioł4
DOI: 10.5603/RPOR.a2022.0105
·
Rep Pract Oncol Radiother 2022;27(6):1037-1044.
Affiliations
  1. Institute of Psychology, Pedagogical University in Kraków, Krakow, Poland
  2. Division of Diagnostic Imaging Department of Radiology and Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia Katowice, Katowice, Poland
  3. Diplomstudium Humanmedizin, Medizinische Universität Wien, Wien, Austria
  4. Department of Paediatric Oncology, Haematology and Chemotherapy, Medical University of Silesia, Katowice, Poland

open access

Vol 27, No 6 (2022)
Original research articles
Published online: 2022-10-03

Abstract

Background: The aim of the study was to determine the relationship between a damaged cerebellum area and the cognitive performance of medulloblastoma tumour survivors. Also, age-based differences in cognitive performance were tested. 

Materials and methods: Magnetic resonance imaging (MRI) technique was used to obtain brain images of survivors. The cognitive performance was tested using Wechsler Intelligence Scale for Children Revised (WISC-R) and Wechsler Adult Intelligence Scale (WAIS). Statistical analysis was performed with highly robust permutation tests.

Results: There were two anatomical features strongly influencing the cognitive performance of survivors. The extension of the foramen of Luschka had a negative impact on the overall verbal IQ score and some non-verbal scales while the excision of the middle part of the vermis influenced scores in such scales as arithmetic and picture completing.

Conclusions: Children with postoperative damages in the area of the middle part of the vermis are more likely to suffer from cognitive dysfunctions after the end of the treatment. 

Abstract

Background: The aim of the study was to determine the relationship between a damaged cerebellum area and the cognitive performance of medulloblastoma tumour survivors. Also, age-based differences in cognitive performance were tested. 

Materials and methods: Magnetic resonance imaging (MRI) technique was used to obtain brain images of survivors. The cognitive performance was tested using Wechsler Intelligence Scale for Children Revised (WISC-R) and Wechsler Adult Intelligence Scale (WAIS). Statistical analysis was performed with highly robust permutation tests.

Results: There were two anatomical features strongly influencing the cognitive performance of survivors. The extension of the foramen of Luschka had a negative impact on the overall verbal IQ score and some non-verbal scales while the excision of the middle part of the vermis influenced scores in such scales as arithmetic and picture completing.

Conclusions: Children with postoperative damages in the area of the middle part of the vermis are more likely to suffer from cognitive dysfunctions after the end of the treatment. 

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Keywords

medulloblastoma; cognitive performance; cerebellum; MRI

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About this article
Title

Cognitive performance of medulloblastoma tumour survivors related to the area of cerebellum damage

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 27, No 6 (2022)

Article type

Research paper

Pages

1037-1044

Published online

2022-10-03

Page views

442

Article views/downloads

34

DOI

10.5603/RPOR.a2022.0105

Bibliographic record

Rep Pract Oncol Radiother 2022;27(6):1037-1044.

Keywords

medulloblastoma
cognitive performance
cerebellum
MRI

Authors

Natalia Maja Józefacka
Magdalena Dagmara Machnikowska-Sokołowska
Mateusz Franciszek Kołek
Katarzyna Jadwiga Gruszczyńska
Katarzyna Musioł

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