Dose homogeneity in the group of 15 patients undergoing fractionated total body irradiation

Abstract

Methods

Fractionated total body irradiation (FTBI) before bone marrow transplantation (BMT) was performed in 15 patients with different proliferative diseases.

Common regimen of 12 Gy in 8 fractions (four days) was applied with the reduction of dose to lungs to 9.4 Gy.

Results

Midline dose discrepancies ranged from −15.9% to +9.9% and exceeded ±10% of prescribed dose in one patient. Outside midline dose discrepancies ranged from −16.5% to +19.8% and exceeded ±10% of prescribed dose in six patients.

Dose determination error was estimated for between 2.8% and 5% depending on the body part.

Conclusions

Estimated error of the dose determination increased dose deviations from prescribed values from between −1.6% and +4.8% to between −5.2% and +9.3% in midline and from −8.4% and +19.8% to between −12.0% and +24.8% across transverses.