Clinical radiobiology of HDR Cf-252 brachytherapy for cervix uterine carcinoma

Abstract

Introduction

Cf-252 neutron brachytherapy is advantgeous to use for treatment of radioresistant tumors.

Material and methods

45 pts. (I) with cervix carcinoma received combined radiation therapy: external Co-60 gamma therapy (37.3 Gy) for pelvis and HDR Cf-252 brachytherapy (point A-35.4 Gy-eq).

Results

The treatment results were compared with historical similar group – 64 pts (II) treated by external Co-60 gamma therapy (39.7 Gy) and HDR Co-60 brachytherapy (point A-47.4 Gy). There were no significant difference in 4 year survival: 73.3% (I) vs 79.7% (II). Local failure was observed in 22.2% (I) and 10.9% (II) cases. The rate of late radiation complications was simiral – 4.4% (I) vs 1.6% (II). Acute reactions were brachytherapy dose dependent with ED50:80.1 Gy-eq and 74.5 Gy in I and II groups respectively.

Conclusions

Radiobiological analysis of obtained data show some possibilities to improve treatment results in HDR Cf-252 brachytherapy group.