open access

Vol 2, No 1 (1997)
Original papers
Published online: 1997-01-01
Submitted:
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Acute and consequential mucosal radiation reactions in patients with head and neck cancer treated by continuous accelerated irradiation (CAIR)

K. Składowski, R. Tarnawski, M. Golen, B. Pilecki, W. Przeorek, M. Syguła, A. Wygoda, B. Maciejewski
DOI: 10.1016/S1428-2267(97)70104-2
·
Rep Pract Oncol Radiother 1997;2(1):11-20.

open access

Vol 2, No 1 (1997)
Original papers
Published online: 1997-01-01
Submitted:

Abstract

Acute mucosal and late radiation responses on continuous accelerated irradiation (CAIR) were evaluated and compared with a conventional treatment (control arm) in 85 patients with head and neck cancer. Confluent mucositis was significantly more severe and maximum score lasting longer in CAIR than in control arm. In the CAIR group 5 (22%) late effects (osteo- and soft tissue necrosis) occured early during 2–4 month of follow-up compare to 5% (1 patient) in control group. There was significant correlation between severity of acute reactions and these late effects in CAIR arm, suggesting that they were consequential. The risk of consequential effects could be predicted by proposed time-area units system of integral acute mucosal reaction.

Abstract

Acute mucosal and late radiation responses on continuous accelerated irradiation (CAIR) were evaluated and compared with a conventional treatment (control arm) in 85 patients with head and neck cancer. Confluent mucositis was significantly more severe and maximum score lasting longer in CAIR than in control arm. In the CAIR group 5 (22%) late effects (osteo- and soft tissue necrosis) occured early during 2–4 month of follow-up compare to 5% (1 patient) in control group. There was significant correlation between severity of acute reactions and these late effects in CAIR arm, suggesting that they were consequential. The risk of consequential effects could be predicted by proposed time-area units system of integral acute mucosal reaction.

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Keywords

accelerated fractionation 7 days per week; head and neck cancer; acute mucositis; consequential late effects

About this article
Title

Acute and consequential mucosal radiation reactions in patients with head and neck cancer treated by continuous accelerated irradiation (CAIR)

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 2, No 1 (1997)

Pages

11-20

Published online

1997-01-01

DOI

10.1016/S1428-2267(97)70104-2

Bibliographic record

Rep Pract Oncol Radiother 1997;2(1):11-20.

Keywords

accelerated fractionation 7 days per week
head and neck cancer
acute mucositis
consequential late effects

Authors

K. Składowski
R. Tarnawski
M. Golen
B. Pilecki
W. Przeorek
M. Syguła
A. Wygoda
B. Maciejewski

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