open access

Vol 1, No 1 (1996)
Papers submitted on II-nd Spring Seminar on Treatment Planning in Radiotherapy. Poznań, Poland 20-21 May 1996
Published online: 1996-01-01
Submitted:
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Strategy of conditionning therapy for hematopoietic cell transplantation

A. Lange, M. Sędzimirska, K. Suchnicki, B. Tomaszewska-Toporska
DOI: 10.1016/S1428-2267(96)70085-6
·
Rep Pract Oncol Radiother 1996;1(1):25-28.

open access

Vol 1, No 1 (1996)
Papers submitted on II-nd Spring Seminar on Treatment Planning in Radiotherapy. Poznań, Poland 20-21 May 1996
Published online: 1996-01-01
Submitted:

Abstract

The rationale behind the use of different conditioning protocols in allotransplanted patients is given. Standard based on Busulfan (Bu) and Cyclophosphamide (Cy) chemotherapy protocol was used for good risk patients and those with a positive history of liver malfunction. In poor risk patients Bu and Cy was supported by ether Etoposide (VP-16) or Thiotepa. Toxicity of the VP-16 consiting chemotherapy was considerably higher than that of BuCy alone. This resulted in a higher transplant related mortality in VP-16 receiving patients. In aplastic anemias (AA) in children Cy was effective in a dose of 200 mg/kg b.w. given prior transplantation. In poor risk patients with severe AA anti-thymocyte globulin (ATG) was used. In Fanconi anemia ATG plus low dose of Cy proved to be succesful in 4 transplanted cases.

Abstract

The rationale behind the use of different conditioning protocols in allotransplanted patients is given. Standard based on Busulfan (Bu) and Cyclophosphamide (Cy) chemotherapy protocol was used for good risk patients and those with a positive history of liver malfunction. In poor risk patients Bu and Cy was supported by ether Etoposide (VP-16) or Thiotepa. Toxicity of the VP-16 consiting chemotherapy was considerably higher than that of BuCy alone. This resulted in a higher transplant related mortality in VP-16 receiving patients. In aplastic anemias (AA) in children Cy was effective in a dose of 200 mg/kg b.w. given prior transplantation. In poor risk patients with severe AA anti-thymocyte globulin (ATG) was used. In Fanconi anemia ATG plus low dose of Cy proved to be succesful in 4 transplanted cases.

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About this article
Title

Strategy of conditionning therapy for hematopoietic cell transplantation

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 1, No 1 (1996)

Pages

25-28

Published online

1996-01-01

DOI

10.1016/S1428-2267(96)70085-6

Bibliographic record

Rep Pract Oncol Radiother 1996;1(1):25-28.

Authors

A. Lange
M. Sędzimirska
K. Suchnicki
B. Tomaszewska-Toporska

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