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Acute pancreatitis during L-asparaginase treatment in children with acute lymphoblastic leukemia
open access
Abstract
L-asparaginase (L-ASPA) has been put to a wide application in many therapeutic protocols, above all in the treatment of acute lymphoblastic leukemia (ALL). We presented three cases of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations. Our observations revealed that ultrasound investigations are very useful in diagnosis and monitoring changes in the pancreas. The use of L-ASPA derivatives allows to decrease the toxic and allergic sequele resulting from the administration of the drug.
Abstract
L-asparaginase (L-ASPA) has been put to a wide application in many therapeutic protocols, above all in the treatment of acute lymphoblastic leukemia (ALL). We presented three cases of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations. Our observations revealed that ultrasound investigations are very useful in diagnosis and monitoring changes in the pancreas. The use of L-ASPA derivatives allows to decrease the toxic and allergic sequele resulting from the administration of the drug.
Keywords
Acute pancreatitis L-asparaginase; ALL
About this articleTitle
Acute pancreatitis during L-asparaginase treatment in children with acute lymphoblastic leukemia
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
15-22
Published online
1999-01-01
DOI
10.1016/S1507-1367(99)70309-3
Bibliographic record
Rep Pract Oncol Radiother 1999;4(1):15-22.
Keywords
Acute pancreatitis L-asparaginase
ALL
Authors
K. Derwich
D. Stencel
M. Warzywoda
M. Leda