open access

Vol 5, No 2 (2000)
Untitled
Published online: 2000-11-01
Submitted: 2000-07-11
Get Citation

Stem cell transplantation for a myelodysplastic syndrome in children

Starý Jan
DOI: 10.1016/S1507-1367(00)70361-0
·
Rep Pract Oncol Radiother 2000;5(2):43-47.

open access

Vol 5, No 2 (2000)
Untitled
Published online: 2000-11-01
Submitted: 2000-07-11

Abstract

The myelodysplastic syndrome (MDS) is a rare, clonal disorder of pluripotent stem cells in children and is characterized by ineffective haematopoiesis, morphologic abnormalities in one or more cell lines in a usually cellular bone marrow, and by predilection for the acute leukaemia. A large proportion of children with MDS present associated clinical abnormalities. Allogeneic stem cell transplantation (SCT) is the only definitive cure for this heterogeneous group of lethal disorders. Results with SCT have been difficult to interpret due to the variability of conditioning regimens, types of donors, and pretransplant therapy. In many series, the outcome with donors other than matched siblings has been extremely poor. The optimal pre-transplant therapy and conditioning regimen for SCT in MDS have not yet been defined. The establishment of several international working groups will eventually help to elucidate the pathogenesis of childhood MDS and will evaluate new treatment strategies to improve their clinical outcome.

Abstract

The myelodysplastic syndrome (MDS) is a rare, clonal disorder of pluripotent stem cells in children and is characterized by ineffective haematopoiesis, morphologic abnormalities in one or more cell lines in a usually cellular bone marrow, and by predilection for the acute leukaemia. A large proportion of children with MDS present associated clinical abnormalities. Allogeneic stem cell transplantation (SCT) is the only definitive cure for this heterogeneous group of lethal disorders. Results with SCT have been difficult to interpret due to the variability of conditioning regimens, types of donors, and pretransplant therapy. In many series, the outcome with donors other than matched siblings has been extremely poor. The optimal pre-transplant therapy and conditioning regimen for SCT in MDS have not yet been defined. The establishment of several international working groups will eventually help to elucidate the pathogenesis of childhood MDS and will evaluate new treatment strategies to improve their clinical outcome.

Get Citation

Keywords

myelodysplastic syndrome (MDS); children; treatment; stem cell transplantation

About this article
Title

Stem cell transplantation for a myelodysplastic syndrome in children

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 5, No 2 (2000)

Pages

43-47

Published online

2000-11-01

DOI

10.1016/S1507-1367(00)70361-0

Bibliographic record

Rep Pract Oncol Radiother 2000;5(2):43-47.

Keywords

myelodysplastic syndrome (MDS)
children
treatment
stem cell transplantation

Authors

Starý Jan

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl