89. Results of the breast conserving therapy in early breast cancer

Abstract

Aim

Evaluation outcome of treatment (surgery and radiotherapy) in early breast cancer.

Material and methods

We performed this analysis on sixty eight women with clinical and pathological diagnosis of the early breast cancer (tumour up to 3 cm and without metastases to the axillary lymph nodes) who were treated in our centre between 1993 and 1995. For all patients in the first phase of treatment the breast conserving surgery (quadrantectomy and axillary dissection) was performed. All patients received radiotherapy (Co60 or photons 6 MeV) to total dose 50,4 Gy, daily fractionation 1,8 Gy prescribed to ICRU point. The electron boost to the tumour bed in some cases was applied. The acute and late morbidity were good, without any grade III (RTOG scale). The follow-up was in range 5 – years.

Results

5 (7%) patients of 68 patients had local recurrence and in these cases total mastectomy was performed. 7 (10%) of 68 patients had distant metastases without locoregional recurrence and chemotherapyin these cases were introduced chemotherapy. Patients with the local recurrence only still alive, but 7 patients with distant metastases died.

Conclusions

Crucial for the outcome of treatment early breast cancer is presence of micrometastases before or during local treatment. The results of combined local treatment were good and in case of local relapse the additional surgery give a chance for cure.